Comprehensive subgroup analyses of survival outcomes between clear cell renal cell adenocarcinoma and papillary renal cell adenocarcinoma

Huang, Jingyi; Huang, Da; Yan, Jiaqi; Chen, Tianhe; Gao, Yi; Xu, Danfeng; Na, Rong

doi:10.1002/cam4.3563

Cited by 4 publications

(6 citation statements)

References 19 publications

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“…Conversely, black patients have more favorable survival outcomes than other races, suggesting that the previous conclusion may not be applicable for pRCC. A large population-based study performed by Huang et al showed that non-Hispanic blacks with metastatic pRCC had a higher survival rate than non-Hispanic whites with metastatic pRCC, further proving our conclusion ( 14 ). In addition to age and race, marital status is another important demographic indicator that affects the natural history of many cancers ( 43 , 44 ).…”

Section: Discussionsupporting

confidence: 82%

“…Large population-based retrospective cohort studies compared the difference in survival outcomes between pRCC and clear-cell RCC, and the results showed that patients with nonmetastatic pRCC were associated with lower cancer-specific mortality than patients with clear-cell RCC ( 13 ). Nevertheless, patients with pRCC presented a significantly high risk of lymph node metastasis, and the oncologic outcomes of patients with metastatic pRCC were generally more unfavorable than those of patients with metastatic clear-cell RCC ( 14 , 15 ). These findings further suggest that there are different survival outcomes between pRCC and clear-cell RCC.…”

Section: Introductionmentioning

confidence: 99%

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A novel nomogram and risk classification system predicting the overall survival of patients with papillary renal cell carcinoma after nephrectomy: A population-based study

Qiao

et al. 2022

Front. Public Health

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BackgroundPapillary renal cell carcinoma (pRCC) is the largest histologic subtype of non-clear-cell RCC. To date, there is no reliable nomogram to predict the prognosis of patients with pRCC after nephrectomy. We aimed to first establish an effective nomogram to predict the overall survival (OS) of patients with pRCC after nephrectomy.MethodsA total of 3,528 eligible patients with pRCC after nephrectomy were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. The patients were randomized into the training cohort (n = 2,472) and the validation cohort (n = 1,056) at a 7:3 ratio. In total, 122 real-world samples from our institute (titled the AHMU-pRCC cohort) were used as the external validation cohort. Univariate and subsequent multivariate Cox regression analyses were conducted to identify OS-related prognostic factors, which were further used to establish a prognostic nomogram for predicting 1-, 3-, and 5-year OS probabilities. The performance of the nomogram was evaluated by using the concordance index (C-index), receiver operating characteristic curve (ROC), calibration plot, and decision curve analysis (DCA).ResultsMultivariate Cox analysis showed that age, race, marital status, TNM stage, tumor size, and surgery were significant OS-related prognostic factors. A prognostic model consisting of these clinical parameters was developed and virtualized by a nomogram. High C-index and area under the ROC curve (AUC) values of the nomogram at 1, 3, and 5 years were found in the training, validation, and AHMU-pRCC cohorts. The calibration plot and DCA also showed that the nomogram had a satisfactory clinical application value. A risk classification system was established to risk-stratify patients with pRCC.ConclusionBased on a large cohort from the public SEER database, a reliable nomogram predicting the OS of patients with pRCC after nephrectomy was constructed, which could optimize the survival assessment and clinical treatment.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

A novel nomogram and risk classification system predicting the overall survival of patients with papillary renal cell carcinoma after nephrectomy: A population-based study

Qiao

et al. 2022

Front. Public Health

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“…Studies have shown that age plays a key role in the survival rate of various cancers ( 22 , 23 ). Huang et al found by propensity matching comparison that pRCC had a significantly worse prognosis than ccRCC in patients aged ≤ 45 years ( 24 ). Su et al collected the SEER database of pRCC patients who underwent nephrectomy from 2010 to 2016 for analysis.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Nomogram to Predict Cancer-Specific Survival in Elderly Patients With Papillary Renal Cell Carcinoma

Zhanghuang

Wang

Yao

et al. 2022

Front. Public Health

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ObjectivePapillary renal cell carcinoma (pRCC) is the second most common type of renal cell carcinoma and an important disease affecting older patients. We aimed to establish a nomogram to predict cancer-specific survival (CSS) in elderly patients with pRCC.MethodsPatient information was downloaded from the Surveillance, Epidemiology, and End Results (SEER) project, and we included all elderly patients with pRCC from 2004 to 2018. All patients were randomly divided into a training cohort and a validation cohort. Univariate and multivariate Cox proportional risk regression models were used to identify patient independent risk factors. We constructed a nomogram based on a multivariate Cox regression model to predict CSS for 1-, 3-, and 5- years in elderly patients with pRCC. A series of validation methods were used to validate the accuracy and reliability of the model, including consistency index (C-index), calibration curve, and area under the Subject operating curve (AUC).ResultsA total of 13,105 elderly patients with pRCC were enrolled. Univariate and multivariate Cox regression analysis suggested that age, tumor size, histological grade, TNM stage, surgery, radiotherapy and chemotherapy were independent risk factors for survival. We constructed a nomogram to predict patients' CSS. The training and validation cohort's C-index were 0.853 (95%CI: 0.859–0.847) and 0.855 (95%CI: 0.865–0.845), respectively, suggesting that the model had good discrimination ability. The AUC showed the same results. The calibration curve also indicates that the model has good accuracy.ConclusionsIn this study, we constructed a nomogram to predict the CSS of elderly pRCC patients, which has good accuracy and reliability and can help doctors and patients make clinical decisions.

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“…Renal cell carcinoma (RCC) is a common urologic malignancy and has increased incidence in recent years 1 . Aside from clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC) is the most common subtype of RCC and accounts for 10%–15% of all RCC cases 2 . The histology of pRCC is characterized by a papillary fibrous vascular core of tumor cells and is markedly different from that of ccRCC 3 .…”

Section: Introductionmentioning

confidence: 99%

“… 1 Aside from clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC) is the most common subtype of RCC and accounts for 10%–15% of all RCC cases. 2 The histology of pRCC is characterized by a papillary fibrous vascular core of tumor cells and is markedly different from that of ccRCC. 3 There are two main histological subtypes of pRCC, depending on their characteristics.…”

Section: Introductionmentioning

confidence: 99%

Identification of potential biomarkers associated with immune infiltration in papillary renal cell carcinoma

Deng

Zhao

et al. 2021

Clinical Laboratory Analysis

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Background Immunotherapeutic approaches have recently emerged as effective treatment regimens against various types of cancer. However, the immune‐mediated mechanisms surrounding papillary renal cell carcinoma (pRCC) remain unclear. This study aimed to investigate the tumor microenvironment (TME) and identify the potential immune‐related biomarkers for pRCC. Methods The CIBERSORT algorithm was used to calculate the abundance ratio of immune cells in each pRCC samples. Univariate Cox analysis was used to select the prognostic‐related tumor‐infiltrating immune cells (TIICs). Multivariate Cox regression analysis was performed to develop a signature based on the selected prognostic‐related TIICs. Then, these pRCC samples were divided into low‐ and high‐risk groups according to the obtained signature. Analyses using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) were performed to investigate the biological function of the DEGs (differentially expressed genes) between the high‐ and low‐risk groups. The hub genes were identified using a weighted gene co‐expression network analysis (WGCNA) and a protein‐protein interaction (PPI) analysis. The hub genes were subsequently validated by multiple clinical traits and databases. Results According to our analyses, nine immune cells play a vital role in the TME of pRCC. Our analyses also obtained nine potential immune‐related biomarkers for pRCC, including TOP2A, BUB1B, BUB1, TPX2, PBK, CEP55, ASPM, RRM2, and CENPF. Conclusion In this study, our data revealed the crucial TIICs and potential immune‐related biomarkers for pRCC and provided compelling insights into the pathogenesis and potential therapeutic targets for pRCC.

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Comprehensive subgroup analyses of survival outcomes between clear cell renal cell adenocarcinoma and papillary renal cell adenocarcinoma

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 19 publications

A novel nomogram and risk classification system predicting the overall survival of patients with papillary renal cell carcinoma after nephrectomy: A population-based study

A novel nomogram and risk classification system predicting the overall survival of patients with papillary renal cell carcinoma after nephrectomy: A population-based study

Development and Validation of a Nomogram to Predict Cancer-Specific Survival in Elderly Patients With Papillary Renal Cell Carcinoma

Identification of potential biomarkers associated with immune infiltration in papillary renal cell carcinoma

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