Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

Kumar, Pawan; Saini, Meenu; Dehiya, Brijnandan S.; Sindhu, Anil; Kumar, Vinod; Kumar, Ravinder; Lamberti, Luciano; Pruncu, Catalin I.; Thakur, Rajesh

doi:10.3390/nano10102019

Cited by 44 publications

(27 citation statements)

References 586 publications

(682 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tissues that have been targeted include skin [ 17 ], bone [ 6 ], cartilage [ 9 , 18 ], vascular [ 19 , 20 ], neural [ 4 , 21 ], or cardiac [ 22 ]. Several reviews have highlighted the use of nanofiber-based scaffolds and give a broad overview on current production processes, characterization techniques, and potential applications [ 1 , 23 , 24 , 25 , 26 , 27 , 28 ]. Such composite materials show great potential in mimicking the naturally occurring extracellular matrix (ECM) by providing optimal structural, chemical, and mechanical stimuli for cellular homeostasis [ 20 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

3D PCL/Gelatin/Genipin Nanofiber Sponge as Scaffold for Regenerative Medicine

2021

View full text Add to dashboard Cite

Recent advancements in tissue engineering and material science have radically improved in vitro culturing platforms to more accurately replicate human tissue. However, the transition to clinical relevance has been slow in part due to the lack of biologically compatible/relevant materials. In the present study, we marry the commonly used two-dimensional (2D) technique of electrospinning and a self-assembly process to construct easily reproducible, highly porous, three-dimensional (3D) nanofiber scaffolds for various tissue engineering applications. Specimens from biologically relevant polymers polycaprolactone (PCL) and gelatin were chemically cross-linked using the naturally occurring cross-linker genipin. Potential cytotoxic effects of the scaffolds were analyzed by culturing human dermal fibroblasts (HDF) up to 23 days. The 3D PCL/gelatin/genipin scaffolds produced here resemble the complex nanofibrous architecture found in naturally occurring extracellular matrix (ECM) and exhibit physiologically relevant mechanical properties as well as excellent cell cytocompatibility. Samples cross-linked with 0.5% genipin demonstrated the highest metabolic activity and proliferation rates for HDF. Scanning electron microscopy (SEM) images indicated excellent cell adhesion and the characteristic morphological features of fibroblasts in all tested samples. The three-dimensional (3D) PCL/gelatin/genipin scaffolds produced here show great potential for various 3D tissue-engineering applications such as ex vivo cell culturing platforms, wound healing, or tissue replacement.

show abstract

Section: Introductionmentioning

confidence: 99%

3D PCL/Gelatin/Genipin Nanofiber Sponge as Scaffold for Regenerative Medicine

2021

View full text Add to dashboard Cite

show abstract

“…However, the fact that the conjugation reaction may modify the biomolecule conformation and result in the loss of bioactivity is an important issue [ 145 ]. For instance, covalently grafted (chemical coupling process) BMP-2 may affect ectopic bone formation due to unwanted self-crosslinking of BMP-2 during the reaction [ 146 ]. Therefore, many drugs are pre-modified (e.g., conjugation to a PEG spacer) [ 147 ] and drug mimics (GF peptide mimics) [ 148 ] are utilized.…”

Section: Encapsulation Incorporation and Related Delivery Stratementioning

confidence: 99%

Advances in Growth Factor Delivery for Bone Tissue Engineering

Oliveira

Nie

Podstawczyk

et al. 2021

IJMS

133

View full text Add to dashboard Cite

Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed to some extent by tissue engineering and regenerative medicine. Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecules to promote osteoinduction and angiogenesis essential in the formation of new bone tissues. Although recent studies on developing novel growth factor delivery systems for bone repair have attracted great attention, taking into account the complexity of the extracellular matrix, scaffolding and growth factors should not be explored independently. Consequently, systems that combine both concepts have great potential to promote the effectiveness of bone regeneration methods. In this review, recent developments in bone regeneration that simultaneously consider scaffolding and growth factors are covered in detail. The main emphasis in this overview is on delivery strategies that employ polymer-based scaffolds for spatiotemporal-controlled delivery of both single and multiple growth factors in bone-regeneration approaches. From clinical applications to creating alternative structural materials, bone tissue engineering has been advancing constantly, and it is relevant to regularly update related topics.

show abstract

“…AuNPs have been recruited for therapeutic efficacy owing to their large surface areas, enabling the adsorption of several functional molecules on their surfaces. However, they have limited applications owing to their toxicity [ 130 , 131 , 132 ]. To address these concerns, Kalmodia et al (2017) developed green synthesis methodology for the synthesis of gold nanoparticles (GNPs) using extracts of Vitus vinifera [ 133 ].…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma

et al. 2021

View full text Add to dashboard Cite

Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approaches to address these concerns. For this purpose, nanotechnology has revolutionized the field of medicine with versatile potential capabilities for both the diagnosis, as well as the treatment, of retinoblastoma via the targeted and controlled delivery of anticancer drugs via binding to the overexpressed retinoblastoma gene. Nanotechnology has also generated massive advancements in the treatment of retinoblastoma based on the use of surface-tailored multi-functionalized nanocarriers; overexpressed receptor-based nanocarriers ligands (folate, galactose, and hyaluronic acid); lipid-based nanocarriers; and metallic nanocarriers. These nanocarriers seem to benchmark in mitigating a plethora of malignant retinoblastoma via targeted delivery at a specified site, resulting in programmed apoptosis in cancer cells. The effectiveness of these nanoplatforms in diagnosing and treating intraocular cancers such as retinoblastoma has not been properly discussed, despite the increasing significance of nanomedicine in cancer management. This article reviewed the recent milestones and future development areas in the field of intraocular drug delivery and diagnostic platforms focused on nanotechnology.

show abstract

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

Cited by 44 publications

References 586 publications

3D PCL/Gelatin/Genipin Nanofiber Sponge as Scaffold for Regenerative Medicine

3D PCL/Gelatin/Genipin Nanofiber Sponge as Scaffold for Regenerative Medicine

Advances in Growth Factor Delivery for Bone Tissue Engineering

Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma

Contact Info

Product

Resources

About