Comprehensive treatment of Cronkhite-Canada syndrome: A case report and literature review

Abstract

Introduction: Cronkhite-Canada syndrome (CCS) is currently considered to be a non-hereditary disease, which is relatively rare clinically. It is also known as polyposis hyperpigmentation alopecia nail dystrophy syndrome, it is a syndrome characterized by gastrointestinal polyposis and ectodermal changes, the main manifestations are gastrointestinal symptoms, skin pigmentation, alopecia, and hypothyroidism. Case presentation: In this paper, the clinical characteristics, diagnosis and treatment of a case of CCS admitted to Huanghe Sanmenxia Hospital were analyzed. In the course of treatment, traditional Chinese medicine was used, but no hormone, and the patient’s clinical symptoms were greatly relieved. Conclusions: CCS is rare, there is no specific treatment, and traditional Chinese medicine may can greatly relieve the clinical symptoms of patients. However, it’s still having to be verified by a large sample, multi-center, long-term treatment follow-up studies.

Comprehensive treatment and a rare presentation of Cronkhite–Canada syndrome: Two case reports and review of literature

“…The average recovery times for diarrhea, taste abnormality, and ectodermal changes in patients with CCS are 51, 84, and 9 d, respectively, and the mean times to resolution of gastric and colonic polyps are 248 and 238 d, respectively[ 23 ]. Currently, there are no standard treatment guidelines, including duration of treatment, with most CCS patients receiving comprehensive empirical treatment based on glucocorticoids.…”

A case report of Cronkhite–Canada syndrome first encounterd at a hospital in northern Vietnam

“…CCS is a rare multiple gastrointestinal polyps and its aetiology and pathogenesis are currently unclear 6 . Gastrointestinal symptoms are the main manifestations, including abdominal pain, diarrhoea, and dysgeusia.…”

“…There is no consensus on the treatment of CCS. In general, the patients received immunosuppressive therapy with corticosteroids or long-term azathioprine therapy, nutritional and micronutrient supplements, in addition to endoscopic monitoring and resection of the remaining large polyps to prevent cancer 6 , 9 , 17 . In this case, we treated the patient with a corticosteroid, nutritional supplementation, or a nutritionally balanced liquid diet, antibiotics, PPI, and capsules to modulate intestinal flora control symptoms and provide support.…”