Comprehensive two-dimensional gas chromatography thermodynamic modeling and selectivity evaluation for the separation of polychlorinated dibenzo-p-dioxins and dibenzofurans in fish tissue matrix

Stultz, Conner; Jaramillo, Roman; Teehan, Paige; Dorman, Frank L.

doi:10.1016/j.chroma.2020.461311

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…Regarding sample size, reviewed studies in this paper revealed that MS-based platforms used 50-5000 mg of tissue 42,117 and 50-200 µl of biofluid, 49,165 while NMR used 20-5000 mg of tissue 87,108 and 17-200 µl for biofluid. 103,185 These variations in sample size across studies demonstrate the need to standardise tissue or biofluid sample mass or volume for traditional metabolomics tools and microgram or microfluidic NMR instruments.…”

Section: Areas For Improvement In Salmonid Metabolomicsmentioning

confidence: 94%

“…Some current use pesticides include mevinphos, ethoprop, dichlorvos, prometryn, terbutryn and triadimefon, and are classified as emerging pollutants 5 . Physiological exposure assessments of aquatic organisms are therefore important to determine for these compounds 117 …”

Section: Research Themes In Salmon Metabolomicsmentioning

confidence: 99%

“…5 Physiological exposure assessments of aquatic organisms are therefore important to determine for these compounds. 117 The first study of metabolic effects of pesticides used LC-MS and tioning. 55 In other toxicity studies of lipid-soluble pesticides found in salmon feed, similar findings were reported.…”

Section: Ecotoxicologymentioning

confidence: 99%

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Metabolomics in salmonid aquaculture research: Applications and future perspectives

Lulijwa

Young

2021

Reviews in Aquaculture

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Salmonids are the third major farmed finfish species after carps and tilapines, and thus contribute to global food fish production. However, as the aquaculture industry continues to grow, several challenges have emerged. Left unchecked, current problems will hinder aquaculture development. Metabolomics is one of the powerful biotechnological tools that will contribute to solving some of the pressing problems. This review aims to summarise findings and identify gaps from studies that used metabolomics in farmed salmon research. We extracted methodological information for comparison, highlighted analytical platform usages and identified most studied salmonids and sample types. We reviewed key articles to highlight the latest research themes.From the identified research gaps, future perspectives regarding potential use of metabolomics to solve issues in ecotoxicology, thermotolerance, nutrition, post-harvest quality, health and disease, and husbandry practices are provided. The survey also highlighted improvements in execution of metabolomics protocols in aquaculture.

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Section: Areas For Improvement In Salmonid Metabolomicsmentioning

confidence: 94%

Section: Research Themes In Salmon Metabolomicsmentioning

confidence: 99%

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Metabolomics in salmonid aquaculture research: Applications and future perspectives

Lulijwa

Young

2021

Reviews in Aquaculture

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“…Multiple efforts were dedicated to developing approaches capable of accurately describing all aspects of the chromatographic separations. This yielded a wide variety of methods, from models describing the kinetics and thermodynamics of the separation to computer-based models [30][31][32][33][34]. Despite these achievements, there is still room for improvement as some aspects may require further refinement to achieve greater accuracy.…”

Section: Theoretical Modelingmentioning

confidence: 99%

Theoretical modeling and machine learning-based data processing workflows in comprehensive two-dimensional gas chromatography—A review

Gaida,

Stefanuto,

Focant

2023

Journal of Chromatography A

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“…Currently, high-resolution mass spectrum-based methods are employed as arbitrary methodologies for both monitoring and quantifying PCDDs at ppt levels, such as high-resolution gas chromatography combined with high-resolution mass spectrometry (HRGC-HRMS), 8 two-dimensional gas chromatography with time-of-flight mass spectrometry (GC × GC-TOF/ MS), 9 and gas chromatography-orbitrap mass spectrometry (GC-Orbitrap/MS). 10 However, the required strictly controlled laboratory conditions for tedious sample preparation, highly skilled operators, and bulky & expensive analytical instruments intuitionally limit the fast and economical detection of PCDDs.…”

mentioning

confidence: 99%

Zr-MOF-Induced Smart Accumulation Enables Surface-Enhanced Raman Spectroscopic Detection of Dioxin at ppt Level in Food Samples

Cheng

et al. 2023

ACS Sens.

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The fast and economical detection of trace polychlorinated dibenzo-p-dioxins (PCDDs) in food samples by current mass spectrum-based methods is hindered by tedious sample preparation and bulky & expensive analytical instruments. Surface-enhanced Raman spectroscopy (SERS) successfully detects many organic pollutants in foods but not dioxins because the employed metal nanoparticles weakly adsorb hydrophobic PCDDs. Herein, we report the detection of PCDDs in milk with SERS for the first time using a bifunctional substrate consisting of Au nanoparticles embedded in a zirconium-based metal–organic framework shell (AuNP/Zr-MOF). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), as the most toxic PCDD, is detected as low as 1.2 parts per trillion (ppt) in real milk samples with massive interfering substances in 30 min, which is the lowest among all reported methods. The aromatic rings of Zr-MOF promote the smart accumulation of TCDD through π–π interactions, and Au–Cl interactions drive TCDD onto Au surfaces. Zr-MOF shells with pore sizes of 12.7 and 20 Å block the accessibility of larger interfering molecules. A one-step apparatus and protocol are established to be superior to traditional methods in terms of time and cost. This work provides new insight into a rational screening method for the detection of persistent organic pollutants in a real sample matrix.

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Comprehensive two-dimensional gas chromatography thermodynamic modeling and selectivity evaluation for the separation of polychlorinated dibenzo-p-dioxins and dibenzofurans in fish tissue matrix

Cited by 7 publications

References 34 publications

Metabolomics in salmonid aquaculture research: Applications and future perspectives

Metabolomics in salmonid aquaculture research: Applications and future perspectives

Theoretical modeling and machine learning-based data processing workflows in comprehensive two-dimensional gas chromatography—A review

Zr-MOF-Induced Smart Accumulation Enables Surface-Enhanced Raman Spectroscopic Detection of Dioxin at ppt Level in Food Samples

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