Comprehensive understanding on solubility and solvation performance of curcumin (form I) in aqueous co-solvent blends

Ursolic Acid and Oleanolic Acid Dissolved in Methanol/Acetone + Water Blends: Thermodynamic Solubility, Intermolecular Interactions, and Solvation Behavior

“…On the other hand, for the solute of UA, the minimum negative magnitudes are δ x 1,3 = (−2.303 to −2.186) × 10 –2 for methanol (1) mixes and δ x 1,3 = (−5.762 to −4.437) × 10 –2 for acetone (1) mixes. A number of previous experiments ,,− have discovered the processes that are comparable to the ones that are described before for the preferential solvation of OA and UA. The result is consistent with the solvent influence on the enhancement of the water network pattern in aqueous solution systems .…”

“…For the purpose of carrying out the KAT-LSER study and elucidating the influence of solvent properties upon the variation in OA and UA solubility, the α, β, π*, and δ H at 298.15 K for methanol + water and acetone + water solutions across the whole methanol/acetone compositions are obtained from previous research and compiled in Table S1 of the Supporting Information section. The reasonable representation needs to be consistent with the physics and chemistry features of the solid dissolution process, which pertains to the fact that solute–solvent interactions favor the dissolution process, while solvent–solvent interactions present the opposite influence. ,,− The KAT-LSER examination of the solvent influence on the OA and UA solubility variation in methanol + water and acetone + water leads to eqs and , respectively. These equations are the best representations generated from the solubility data regression. .25ex2ex ln ⁡ x = − 4.648 false( prefix± 0.342 false) − 2.768 false( prefix± 0.147 false) true( V normals δ normalH 2 100 italicRT true) r 2 = 0.94 ; n = 22 .25ex2ex ln ⁡ x = − 4.687 false( prefix± 0.481 false) − 2.645 false( prefix± 0.206 false) true( V normals δ normalH 2 100...…”

“…They are (1) the van’t Hoff–Jouyban–Acree model , and the Jouyban–Acree model, ,,, which describe the dependence of saturated solubility (quantified on a mole fraction scale) on solvent proportion and experimentation temperature; (2) the modified Wilson model, which is a description of the solubility magnitude dependence at a certain temperature on the solvent composition; and (3) the Apelblat model, , which is a description of the solubility dependence at a fixed solvent composition on temperature. In addition, the KAT-LSER − ,, is utilized to investigate the solvent effect quantitatively, and the inverse Kirkwood–Buff integrals (IKBIs) − is applied to the OA and UA solubility to investigate the preferential solvation, wherein the densities of acetone (1) + water (2) solutions are obtainable, as shown in ref . Mathcad 15 is a piece of software used to perform all computation processes.…”

“…Using binary solvent mixtures to modify the solubility of a solute is a highly flexible and potent technique. , The systematic determination of the pharmaceutical solubility in aqueous solutions is essential from both a theoretical and practical standpoint. This is due to the fact that when one has a thorough grasp of the thermodynamic solubility in aqueous solution systems, one may obtain helpful information on the solute–solvent interactions and the solvation performance of medicines by cosolvent species. − Cosolvency technology in the pharmaceutical field as a highly effective solubilization method has long been recognized. − Regardless of this, researchers have just begun to investigate the processes responsible for the decrease or increase in solid solubility during the past few years. Comprehending the solubility behavior and dissolution mechanisms of solids in cosolvents can provide a wide-ranging description of several physicochemical parameters in connection to the pharmaceutical dissolving process. , In addition, even though there are a number of prediction models that may be used to estimate the solubilities of drugs in aqueous cosolvent systems, ,, testing is still necessary for scientific study.…”

Solubility Modeling of a Bupivacaine Hydrochloride in Various Solvents over a Wide Temperature Range

“…The modified Jouyban–Acree model is produced by relating the Jouyban–Acree model and the modified Apelbalt model, , which can be simplified and described as follows ln ⁡ x = A 1 + A 2 T + A 3 ln ⁡ T + A 4 x 2 + A 5 x 2 T + A 6 ( x 2 ) 2 T + A 7 false( x 2 false) 3 T + A 8 ( x 2 ) 4 T + A 9 x 2 ln ⁡ T where A 1 to A 9 represent model parameters and are listed in Table .…”