An accurate and cost effective zig-zag plate model with variable kinematics and fixed degrees of freedom recently developed by the authors, which a priori fulfills the stress and displacement continuity requirements, is applied to study indentation of sandwiches with honeycomb/foam core. The variable elastic properties of the core during crushing are evaluated apart and once at a time through a 3D finite element analysis. Shell elements with elastic-plastic isotropic properties are adopted to discretize honeycomb cores and faces, instead solid elements with nonlinear material behavior are used for foam cores. To keep low the computational burden, the structural response is computed in closed form by the zig-zag model using these elastic properties. The damage analysis is carried out through a mesoscale model that determines the degraded properties of failed regions in a physically consistent way. A good agreement with experiments taken from the literature being shown, the present simulation procedure with a low computational effort is proven to be an efficient alternative to the ones currently employed.