Compression-coated tablets of glipizide using hydroxypropylcellulose for zero-order release: In vitro and in vivo evaluation

Poly(2-Ethyl-2-Oxazoline) as an Alternative to Poly(Vinylpyrrolidone) in Solid Dispersions for Solubility and Dissolution Rate Enhancement of Drugs

“…Glipizide is a second generation of sulfonylureas ( Figure 2), a class of drug used to treat non-insulin dependent diabetes mellitus (NIDDM) or type 2 diabetes, which characterized in both tissue insulin resistance and insulin secretion deficiency (17). To date, several attempts have been made to improve the solubility of glipizide, including preparation of solid dispersion with polyvinyl acetate phthalate, hydroxypropyl methylcellulose (18), poloxamer (19) and polyethylene glycol (20); formation of cyclodextrin complex (21)(22)(23), nanosuspension (24), microparticles (25) and co-solvent solubilization (26). In the present study, we aimed to introduce PEOX as a novel carrier for solid dispersion preparation and investigate glipizide-PEOX solid dispersion as a new model system and compare it with glipizide-PVP solid dispersion in terms of solubility and dissolution behavior.…”

Combining Cellulose and Cyclodextrins: Fascinating Designs for Materials and Pharmaceutics

“…A zero-order release kinetics of glipizide, used as model drug, from compression-coated tablets for oral administration, was observed by Huang et al ( 2013 ), using HPC as the coating layer. Those tablets were able to form a hydrogel, when in contact with the gastrointestinal fluid, which decreased the drug release rate.…”

“…Cyclodextrins (CDs) and cellulose are fascinating molecules with synergistic properties that have been critical for preparing new derivatives directed at several innovative applications, ranging from textiles (El Ghoul et al, 2016 ; Mihailiasa et al, 2016 ) coatings (Huang et al, 2013 ; Shah et al, 2015 ; Mihailiasa et al, 2016 ; Umoren and Eduok, 2016 ; Jimenez et al, 2017 ), sensors (Qiu and Hu, 2013 ) and paper making to pharmaceutical technology (Siepmann and Peppas, 2001 ; Hadjichristidis et al, 2003 ; Zhang et al, 2012 ; Shokri and Adibkia, 2013 ; Yang and Yang, 2013 ; Mogosanu and Grumezescu, 2015 ; Thakur, 2015 ; Lalatsa and Barbu, 2016 ; Jawaid and Mohammad, 2017 ; Nishio et al, 2017 ; Yadav et al, 2018 ). Cellulose has been considered a suitable matrix for preparing polymers containing CDs.…”

Palmitic Acid–Pluronic F127–Palmitic Acid Pentablock Copolymer as a Novel Nanocarrier for Oral Delivery of Glipizide

“…4 After absorption from the gastrointestinal tract, glipizide reduces the blood glucose levels in 30 min and peak concentration of the drug is reached within 1-3 h. 3 It is rapidly eliminated from the body due to its small biological half-life (3.4±0.7 h) and hence the drug needs frequent oral administration in 2 or 3 doses of 2.5 to 10 mg per day. 5 Due to the poor solubility of glipizide, researchers have investigated several drug delivery systems including a solid self-nanoemulsifying drug delivery system, 2 microspheres, 5 poly(lactic-co-glycolic acid), Eudragit nanoparticles, 6 cyclodextrin complex, 7,8 chitosan and xanthan beads, 9 and nanosuspension 10 to increase the solubility and bioavailability of glipizide. Nanotechnology-based drug delivery systems with the use of biodegradable polymers seem to be most convenient for the delivery of any drug due to negligible chances of toxicity and overall improved therapeutic properties.…”