Compression profiles of different molecular weight chitosans

Al-Akayleh, Faisal; Rashid, Iyad; Al-Omari, Mahmoud M.H.; Al-Sou’od, Khaldoun A.; Chowdhry, Babur Z.; Badwan, Adnan A.

doi:10.1016/j.powtec.2016.05.019

Cited by 19 publications

(17 citation statements)

References 57 publications

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“…A lower P Y value is preferable for plastically deforming materials, as it indicates a higher extent of deformation. The foregoing gives rise to a greater degree of folding, and thus, the appearance of fresh new particle surfaces for bridging with nearby surfaces [47]. Roller compacted powders manifested a high extent of plastic deformation compared to ball milled chitin which, in turn, displayed greater plasticity than the raw chitin.…”

Section: Discussionmentioning

confidence: 99%

Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin

et al. 2020

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Chitin has been investigated in the context of finding new excipients suitable for direct compression, when subjected to roller compaction. Ball milling was concurrently carried out to compare effects from different energy or stress-inducing techniques. Samples of chitin powders (raw, processed, dried and humidified) were compared for variations in morphology, X-ray diffraction patterns, densities, FT-IR, flowability, compressibility and compactibility. Results confirmed the suitability of roller compaction to convert the fluffy powder of raw chitin to a bulky material with improved flow. X-ray powder diffraction studies showed that, in contrast to the high decrease in crystallinity upon ball milling, roller compaction manifested a slight deformation in the crystal lattice. Moreover, the new excipient showed high resistance to compression, due to the high compactibility of the granules formed. This was correlated to the significant extent of plastic deformation compared to the raw and ball milled forms of chitin. On the other hand, drying and humidification of raw and processed materials presented no added value to the compressibility and compactibility of the directly compressed excipient. Finally, compacted chitin showed direct compression similarity with microcrystalline cellulose when formulated with metronidazole (200 mg) without affecting the immediate drug release action of the drug.

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Section: Discussionmentioning

confidence: 99%

Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin

et al. 2020

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“…The trend observed shows that the porosity of the compact decreases with increasing compaction pressure for all the materials. This occurred as a result of extensive packing occurring at higher compaction pressures leading to lower porosities (Alakayleh et al, 2016). There was a slight difference in the extent of porosity reduction obtained with SAS-CG compared with the other two materials.…”

Section: Fig 4 Compaction Plots Of Sas-cd Sas-cf and Sas-cg (A) Hmentioning

confidence: 92%

“…Contrastingly, the Walker model is more robust and less sensitive to the approach used (Ilić et al, 2013). Notwithstanding, Heckel and Walker analysis have been able to predict and determine optimum tableting properties usually obtained with plastic and brittle fracture deforming materials (Alakayleh et al, 2016).…”

Section: Fig 4 Compaction Plots Of Sas-cd Sas-cf and Sas-cg (A) Hmentioning

confidence: 99%

“…At lower pressures, the porosities of compacts obtained with SAS-CD and SAS-CF were lower than that of SAS-CG. This has been attributed to the larger particle size of SAS-CG which requires more work of compression to rearrange the particles, deform and finally to fragment them (Alakayleh et al, 2016). However, at higher pressures where particle fragmentation must have taken place to fill up the interparticulate pores during rearrangement coupled with plastic deformation, the extent of porosity reduction observed with SAS-CG seem to surpass the other two yielding compacts with lower porosity.…”

Section: Fig 4 Compaction Plots Of Sas-cd Sas-cf and Sas-cg (A) Hmentioning

confidence: 99%

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Comparative analysis of co-processed starches prepared by three different methods

Apeji¹,

Aluga²,

Olayemi³

et al. 2017

British Journal of Pharmacy

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Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that cogranulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of coprocessing influences the powder and tableting properties of the co-processed excipient.

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“…The increase in water absorption causes the formation of more PEC layers which results in potentially more drug retardation. The aforementioned claim was supported by the slow release of diclofenac sodium from low molecular weight CS tablets (13 and 30 kDa) [92]. AlAkayleh et al, found that the release rate of terbutaline sulfate from XG-low molecular weight CS tablets (viscosity 38 mPa s) was slower than XG-high molecular weight CS (70 mPa s) [48].…”

Section: Molecular Weight (Mw) Of Csmentioning

confidence: 97%

An Overview of Chitosan-Xanthan Gum Matrices as Controlled Release Drug Carriers

Dadou¹,

Antonijević²,

Chowdhry³

et al. 2018

Chitin-Chitosan - Myriad Functionalities in Science and Technology

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Naturally occurring polysaccharides and/or their chemically modified derivatives have been widely investigated in relation to their use as components of controlled release systems for drug delivery. The aforementioned is due, in part, to their distinct properties such as abundant availability and biocompatibility as well as environmental and economic advantages. Chitosan (CS) and xanthan gum (XG) based matrices have received growing scientific/pharmaceutical interest as oral controlled release drug carriers. Herein, recent advances spanning the last two decades in CS-XG based drug delivery systems are reviewed with the emphasis being on oral tablet formulations, due to their versatility as pharmaceutical dosage forms. The mechanism of interaction between CS and XG, by means of computational and experimental approaches, is scrutinized. Results obtained from the literature establish the possibility of fabricating a controlled release drug delivery system based on CS and XG matrices. This can be achieved by monitoring and manipulating the physiochemical properties of the two polymers as well as the experimental variables affecting their drug retardation efficiency, without the need to employ special equipment or sophisticated experimental techniques/methodologies.

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Compression profiles of different molecular weight chitosans

Cited by 19 publications

References 57 publications

Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin

Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin

Comparative analysis of co-processed starches prepared by three different methods

An Overview of Chitosan-Xanthan Gum Matrices as Controlled Release Drug Carriers

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