Compression stockings attenuate the expression of proteins associated with vascular damage in human varicose veins

Moñux, Guillermo; Serna-Soto, Mariano de la; Plá-Sanchez, Ferrán; Zamorano-León, José J.; Segura, Antonio; Rial, Rodrigo; Freixer, Gala; Zekri-Nechar, Khaoula; Hugo-Martínez, Carlos; Serrano, Javier; López‐Farré, Antonio

doi:10.1016/j.jvsv.2020.05.020

Cited by 10 publications

(8 citation statements)

References 36 publications

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“…According to the results of the present trial, which are supported by coherent data from the literature, it is not justified to recommend compression stockings in addition to LMWH and NSAIDs for prolonged time periods, but they might have beneficial effects early in the disease process [19]. Some studies also confirm that compression stocking therapy in the varicose vein wall may change the levels of biomarkers associated with vein insufficiency [21]. A higher level of class II GECS in our study led to a significant reduction of symptoms, equivalent to a greater effect on venous hypertension.…”

Section: Discussionsupporting

confidence: 66%

The effect of graduated elastic compression stockings on clinical findings, complications and inflammatory and thrombotic markers in patients with superficial vein thrombophlebitis

et al. 2021

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Introduction/Objective. Assessment of the effect of graduated elastic compression stockings on clinical findings, complications and inflammatory and thrombotic markers in patients with superficial vein thrombophlebitis. Methods. This prospective study was conducted between January and July 2017, in the Clinic for Vascular and Endovascular Surgery of Clinical Centre of Serbia. All the patients were clinically examined, and color duplex ultrasonography of the superficial and deep venous systems was performed. In all cases we follow clinical finding, inflammatory and thrombotic markers and complication superfitial vein thrombosis (SVT). Results. SVT was detected in 60 patients (36 women, aged from 23 to 75 and 24 men, aged from 18 to 76. Most patients were with unilateral, subacute, above knee located SVT. Regarding the typical clinical symptoms of SVT, patients were divided in four groups. Majority of our patients (group D) had all symptoms associated. Regarding the severity of SVT and risk factors, patients were divided into a greater risk group (Group I) and a lesser risk group (Group II), and treated with low-molecular-weight heparin (LMWH) aspirin (ASA)and two classes of GECS regarding the level of SVT. Laboratory testing of inflammatory and thrombotic markers in patients with SVT was performed at the beginning and at the end of therapy Conclusions. In treatment of superficial venous thrombosis higher class of graduated compression therapy has stronger influence in decrement of inflammatory and thrombotic factors and prompt and adequately chosen therapy of superficial venous thrombosis allows stoppage and regression of thrombotic process.

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Section: Discussionsupporting

confidence: 66%

The effect of graduated elastic compression stockings on clinical findings, complications and inflammatory and thrombotic markers in patients with superficial vein thrombophlebitis

et al. 2021

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“…Zudem konnte ein signifikanter Rückgang der Matrixmetalloproteinasen (MMP)-3, -8 und -9 gezeigt werden [36]. Darüber hinaus kommt es zu einem Anstieg von Nitric Oxid Synthase 3 und Reduktion von Interleukin-6 sowie P-Selectin [37]. Insbesondere bei okkludierenden Gefäßkrankheiten wie LV können auch die fibrinolytischen Effekte der Kompressionstherapie diskutiert werden [38].…”

Section: Wirkung Der Kompressionstherapieunclassified

Kompressionstherapie bei entzündlichen Dermatosen der Beine

Dissemond,

Eder,

Läuchli

et al. 2024

Dtsch Med Wochenschr

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ZusammenfassungEs gibt zunehmend wissenschaftlich belegte Hinweise darauf, dass entzündliche Dermatosen der Beine neben venösen und lymphatischen Krankheitsbildern Indikationen für Kompressionstherapie sind. Konkret sind es Erkrankungen, wie Pyoderma gangraenosum, Livedovaskulopathie, kutane Vaskulitiden, Necrobiosis lipoidica, Psoriasis oder Erysipel, bei denen eine begleitende Kompressionstherapie bei einer Manifestation an den unteren Extremitäten durchgeführt werden kann. Wenn entzündliche Dermatosen mit einem Ödem einhergehen, handelt es sich bei der Kompressionstherapie nicht um einen Off-Label-Use. Insbesondere aufgrund der oft problematischen Schmerzsymptomatik kann gerade bei entzündlichen Dermatosen die Kompressionstherapie mit niedrigen Ruhedruckwerten um 20 mmHg durchgeführt werden.In diesem Übersichtsbeitrag werden die aktuellen wissenschaftlichen Aspekte der Kompressionstherapie bei entzündlichen Dermatosen der Beine und die entsprechenden Limitationen differenziert dargestellt.

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“…Additionally, it has been observed that compression therapy promotes the release of anti‐inflammatory mediators from endothelial cells 8 . For example, there is an increase in nitric oxide synthase 3 and a decrease in interleukin‐6 and P‐selectin with compression therapy 9 …”

Section: Physical and Physiological Basicsmentioning

confidence: 99%

Compression therapy in dermatology

Dissemond

Protz

Stücker

2023

J Deutsche Derma Gesell

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SummaryCompression therapy is a conservative therapy that can be used in many patients with dermatological conditions, especially those associated with edema. In addition to its well‐established use in venous and lymphatic disorders, there is increasing evidence that compression therapy supports the healing of inflammatory dermatoses. The presence of edema, regardless of its etiology, is an indication for the use of compression therapy.Nowadays, a variety of materials and treatment options are available for compression therapy, each with their own advantages and disadvantages. Often, compression therapy with low resting pressures is sufficient for effective therapy and is better tolerated by patients. The main contraindications to compression therapy are advanced peripheral arterial disease and decompensated heart failure.Individual factors and economic considerations should be taken into account when deciding on compression therapy with the patient. Patient self‐management should be encouraged whenever possible. This requires education and support tools.

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Compression stockings attenuate the expression of proteins associated with vascular damage in human varicose veins

Cited by 10 publications

References 36 publications

The effect of graduated elastic compression stockings on clinical findings, complications and inflammatory and thrombotic markers in patients with superficial vein thrombophlebitis

The effect of graduated elastic compression stockings on clinical findings, complications and inflammatory and thrombotic markers in patients with superficial vein thrombophlebitis

Kompressionstherapie bei entzündlichen Dermatosen der Beine

Compression therapy in dermatology

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