Compression Therapy to Prevent Recurrent Cellulitis of the Leg

Webb, Elizabeth; Neeman, Teresa; Bowden, Francis J.; Gaida, James Edmund; Mumford, Virginia; Bissett, Bernie

doi:10.1056/nejmoa1917197

Cited by 73 publications

(57 citation statements)

References 25 publications

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“…Lymphedema has been suggested as a risk factor for multiple hospitalizations for cellulitis in previous reports [3,4,9]. In contrast, our study showed no significant difference between the two groups in terms of chronic venous insufficiency, peripheral circulatory disturbance, and deep vein thrombosis.…”

Section: Discussioncontrasting

confidence: 78%

Predictors for readmission due to cellulitis among Japanese patients

Norimatsu

Ohno

2021

The Journal of Dermatology

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Cellulitis is a skin and soft tissue infection that is accompanied by symptoms, such as swelling, flushing, and pain [1]. The main causative bacterial species are group A β-Streptococcus and Staphylococcus aureus [2]. Some patients, especially those with chronic swelling (lymphedema), obesity, and diabetes, are at an increased risk of cellulitis [1,3]. Previous studies have reported that 41% to 45.3% of cellulitis cases eventually recur [4].A recurrence prediction score for the cellulitis of the lower limbs has been developed, and patients with lymphedema, chronic venous insufficiency, peripheral circulatory disturbance, and deep vein thrombosis are considered to be at risk [4]. While this score is expected to be applied clinically, it has limited usefulness because it

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Section: Discussioncontrasting

confidence: 78%

Predictors for readmission due to cellulitis among Japanese patients

Norimatsu

Ohno

2021

The Journal of Dermatology

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“…10,11 Coronary heart disease and DVT could result in chronic edema, and chronic edema is a risk factor for cellulitis and recurrent cellulitis. 12 Furthermore, both coronary heart disease and DVT were confirmed as risk factors for sepsis. 13 The management of MSKI depends on quick and accurate recognition of pathogenic microorganisms and a thorough identification of the infection site and tissue involved.…”

Section: Dovepressmentioning

confidence: 98%

Clinical Features and Etiology of Musculoskeletal Infection with or without Sepsis in the Emergency Department

Zhang

Huang

et al. 2021

IJGM

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Background: Musculoskeletal infection (MSKI) is a common reason to seek medical care in the emergency department (ED). We aimed to determine the clinical characteristics and etiology of patients with MSKI in our ED, the characteristics of MSKI with sepsis, and the predictors of death in sepsis patients. Methods: The study retrospectively analyzed patients with MSKI from April 1, 2017, to March 31, 2021. The patients were divided into non-sepsis and sepsis groups. Clinical data of these patients including their basic information, laboratory results, diagnostic results, and outcomes were collected. Statistical analysis was carried out using GraphPad Prism 5. Results: In all, 106 patients (70 male, 36 female) were enrolled in this study: 43 MSKI patients with sepsis and 63 MSKI patients without sepsis. Five patients with sepsis died. The patients' age and sex ratio were no significantly different between the sepsis and non-sepsis groups. In the sepsis group, the ratio of rheumatic diseases, diabetes, coronary heart disease, and deep vein thrombosis was significantly different than that in the non-sepsis group (all p<0.05). Fifty-six patients (54.37%) had positive etiology results. Staphylococcus, streptococcus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli were the most common bacteria found in both groups, but sepsis patients had more Candida albicans infections than non-sepsis patients (p=0.0331, p<0.05). The five patients who died in the sepsis group had higher serum levels of creatinine and procalcitonin (PCT). Multivariate logistic regression analyses showed that PCT (p=0.026; odds ratio, 1.038) was significantly related to mortality. Conclusion:In MSKI patients, rheumatic diseases, diabetes, coronary heart disease, and deep vein thrombosis are the risk factors for sepsis. Staphylococcus, streptococcus, K. pneumoniae, P. aeruginosa, and E. coli were the most common bacteria in MSKI patients, while MSKI patients with sepsis had more C. albicans infections. Elevated PCT was significantly related to death in sepsis patients.

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“…Compression therapy is increasingly gathering attention as a treatment for lymphedema and is known to prevent recurrence 3 . It is noteworthy that LVA, as a treatment for lymphedema, may also prevent the recurrence of cellulitis.…”

Section: Dear Editormentioning

confidence: 99%

“… 2 Compression therapy has been increasingly gathering attention as a treatment of lymphedema and is known to prevent recurrence. 3 In addition, LVA, as a treatment of lymphedema, might also prevent the recurrence of cellulitis. In contrast, Norimatsu and Ohno 4 reported that hyperlipidemia, hypertension, hypoalbuminemia, and lymphedema are significant risk factors for recurrent cellulitis in the Japanese population.…”

mentioning

confidence: 99%

Malnutrition, hypertension, and hyperlipidemia as risk factors for recurrent cellulitis

Norimatsu¹,

Norimatsu

2021

Journal of Vascular Surgery Cases, Innovations and Techniques

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Compression Therapy to Prevent Recurrent Cellulitis of the Leg

Cited by 73 publications

References 25 publications

Predictors for readmission due to cellulitis among Japanese patients

Predictors for readmission due to cellulitis among Japanese patients

Clinical Features and Etiology of Musculoskeletal Infection with or without Sepsis in the Emergency Department

Malnutrition, hypertension, and hyperlipidemia as risk factors for recurrent cellulitis

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