Compressive properties of trabecular bone in the distal femur

Burgers, Travis; Mason, Jim; Niebur, Glen L.; Ploeg, Heidi‐Lynn

doi:10.1016/j.jbiomech.2007.11.018

Cited by 48 publications

(40 citation statements)

References 33 publications

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“…Water jets and air jets were used to remove any excess of water and bone marrow from the bone samples. The bone samples were then dried and stored in a freezer individually in an airtight plastic bag to minimise thermal cycling [3,31,44,45]. The temperature of the freezer was set to -20°C [3,31,[43][44][45].…”

Section: Specimen Preparationmentioning

confidence: 99%

“…For compression testing, the end of each specimen was fixed to stainless steel endcaps via adhesives [14,45]. The endcaps were then placed inside a jig (Fig.…”

Section: Specimen Preparationmentioning

confidence: 99%

“…1b. Load was measured through the Instron load cell with a maximum load capacity of 10 kN [45]. The relative displacement between the endcaps was measured using an extensometer (Instron 2620 Series Dynamic Extensometer, with travel 5 mm/mm and gauge length 12.5 mm/mm).…”

Section: Compression Testingmentioning

confidence: 99%

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Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation

Syahrom

Kadir

Abdullah

et al. 2011

Med Biol Eng Comput

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The relationship between microarchitecture to the failure mechanism and mechanical properties can be assessed through experimental and computational methods. In this study, both methods were utilised using bovine cadavers. Twenty four samples of cancellous bone were extracted from fresh bovine and the samples were cleaned from excessive marrow. Uniaxial compression testing was performed with displacement control. After mechanical testing, each specimen was ashed in a furnace. Four of the samples were exemplarily scanned using micro-computed tomography (μCT) and three dimensional models of the cancellous bones were reconstructed for finite element simulation. The mechanical properties and the failure modes obtained from numerical simulations were then compared to the experiments. Correlations between microarchitectural parameters to the mechanical properties and failure modes were then made. The Young's modulus correlates well with the bone volume fraction with R² = 0.615 and P value 0.013. Three different types of failure modes of cancellous bone were observed: oblique fracture (21.7%), perpendicular global fracture (47.8%), and scattered localised fracture (30.4%). However, no correlations were found between the failure modes to the morphological parameters. The percentage of error between computer predictions and the actual experimental test was from 6 to 12%. These mechanical properties and information on failure modes can be used for the development of synthetic cancellous bone.

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Section: Specimen Preparationmentioning

confidence: 99%

“…For compression testing, the end of each specimen was fixed to stainless steel endcaps via adhesives [14,45]. The endcaps were then placed inside a jig (Fig.…”

Section: Specimen Preparationmentioning

confidence: 99%

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Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation

Syahrom

Kadir

Abdullah

et al. 2011

Med Biol Eng Comput

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“…42 The initial compressive strength (24.0 -4.8 MPa) and modulus (503 -122 MPa) of the BCs exceed values reported for trabecular bone, which range from 3.7 to 8.4 MPa and 104 to 300 MPa, respectively. 39,[43][44][45] Similarly, the ultimate strain of the BCs (7.3% -0.6%) exceeds that of trabecular bone in human femora (1.05% -0.46%) 46 , while the toughness (1072 -292 kJ$m ( 39 )]. Under torsional deformation, the strength and modulus of the BCs are 2.9 -1.4 and 121 -18 MPa, respectively, which are close to values reported for human, 31,47 bovine, 48,49 canine, 43 and ovine 50,51 trabecular bone ranging from 3.1 to 7.7 MPa and 263 to 366 MPa, respectively.…”

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confidence: 99%

Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

Dumas

Prieto

Zienkiewicz

et al. 2014

Tissue Engineering Part A

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There is a compelling clinical need for bone grafts with initial bone-like mechanical properties that actively remodel for repair of weight-bearing bone defects, such as fractures of the tibial plateau and vertebrae. However, there is a paucity of studies investigating remodeling of weight-bearing bone grafts in preclinical models, and consequently there is limited understanding of the mechanisms by which these grafts remodel in vivo. In this study, we investigated the effects of the rates of new bone formation, matrix resorption, and polymer degradation on healing of settable weight-bearing polyurethane/allograft composites in a rabbit femoral condyle defect model. The grafts induced progressive healing in vivo, as evidenced by an increase in new bone formation, as well as a decrease in residual allograft and polymer from 6 to 12 weeks. However, the mismatch between the rates of autocatalytic polymer degradation and zero-order (independent of time) new bone formation resulted in incomplete healing in the interior of the composite. Augmentation of the grafts with recombinant human bone morphogenetic protein-2 not only increased the rate of new bone formation, but also altered the degradation mechanism of the polymer to approximate a zero-order process. The consequent matching of the rates of new bone formation and polymer degradation resulted in more extensive healing at later time points in all regions of the graft. These observations underscore the importance of balancing the rates of new bone formation and degradation to promote healing of settable weight-bearing bone grafts that maintain bone-like strength, while actively remodeling.

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“…On the contrary, the vertebral inner compressive principal strain can be used to represent the drug effects on the purely mechanical conditions of the vertebra. In addition, the yield strain of bone is fairly constant even as the apparent BMD changes (33) and it is considered that the FEAs based on the displacement method used in this study approximate the strain of the bone tissue for high porosity cancellous bone. Besides, the strain values shown in Table 3 are physically reasonable.…”

Section: Evaluations Using Average Compressive Principal Strainsmentioning

confidence: 99%

Patient-Specific Finite Element Analyses Detect Significant Mechanical Therapeutic Effects on Osteoporotic Vertebrae During a Three-Year Treatment

Tawara

Sakamoto

Murakami

et al. 2011

JBSE

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Analyses of the bone mass alone of osteoporotic vertebrae are not sufficient to predict fracture risks and assess the recovery of bone strength during drug treatment. Instead, finite element analyses (FEAs) is superior, because changes in the vertebral strength are strongly dependent on the inner vertebral stress distribution, which is related to the individual bone shape and bone density distribution in cancellous and cortical region. To investigate how FEAs can detect drug effects, we performed patient-specific FEAs of the first lumbar vertebra of osteoporotic patients at five time points (before therapy, and after 6 and 12 months and 2 and 3 years of therapy) during a 3-year drug treatment with alendronate and vitamin D, in four osteoporotic female patients in this study. The FEAs revealed notable decreases in the compressive principal strains in cancellous bone, but these decreases did not necessarily correspond to increases in the bone densities. In addition, statistical analyses by Friedman's test (nonparametric analysis) showed that evaluation based only on the average compressive principal strains over the 3-year treatment identified drug effects significantly, suggesting that compressive principal strain is an useful indicators for monitoring drug effects. Our data implied that compressive fracture of the vertebrae may be prevented as a result of the drug treatment, in a manner that was optimally detectable by patient-specific FEAs.

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Compressive properties of trabecular bone in the distal femur

Cited by 48 publications

References 33 publications

Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation

Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation

Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

Patient-Specific Finite Element Analyses Detect Significant Mechanical Therapeutic Effects on Osteoporotic Vertebrae During a Three-Year Treatment

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