This study aimed to evaluate the durability and engineering performance of concrete mixed with locally produced ground granulated blast-furnace slag (GGBS) based on CaO content and ratio, and to derive the optimal CaO content range that can secure durability. Hence, tests were conducted by increasing the GGBS replacement ratio by 10% from 0% to 70%, while the unit binder weight was fixed at 330 kg/m3. The results indicated that the compressive strength exhibited a tendency to increase when the CaO content and basicity increased within 28 d of age, although similar compressive strength characteristics were observed at 56 d of age, irrespective of the CaO content and basicity. Additionally, four test items (i.e., carbonation depth, chloride penetration depth, relative dynamic elastic modulus, and weight reducing ratio) were measured to evaluate durability. The optimal CaO content satisfying all four parameters was observed as ranging between 53% and 56% (GGBS replacement ratio: 27.5%–47.1%). The results of the study can provide guidelines on the mixing proportions of GGBS concrete with excellent durability that can be applied to local construction sites and can be used as basic data to set chemical composition criteria for the development of binders to improve durability.