Abstract-Process multi-stage centrifugal compressors have a very wide range of applications in oil, gas and petrochemical industries. One of the major applications is in gas pipeline transports. In this paper, design procedure of process multi-stage centrifugal compressor, by considering one dimensional flow design, is presented. By taking into account that the procedure is specially targeted to design a compressor for gas industry and considering that the ability for test of these kinds of compressors is already available at OTCE Company, therefore result achieved by mentioned procedure is compared by empirical data. In addition, aerodynamics and thermodynamics gas flow governing equations are derived and appropriate correction factors are employed in every individual section in order to fulfill complete design procedure. In this procedure, working fluid flow is assumed as one dimensional flow and considered as real gas. Moreover, the procedure is started from calculation of impeller inlet and it is continued for the other sections including impeller exit, diffuser and volute. Besides, total efficiency, stage efficiency, correction factors and leakages are calculated along with other sections calculations. Finally, the obtained design results are compared with experimental data.Index Terms-Centrifugal compressor, multi-stage, design.