Comprometimento respiratório secundário a acidente ofídico crotálico (Crotalus durissus)

Amaral, Carlos Faria Santos; Magalhães, Renato Almeida; Rezende, Nilton Alves de

doi:10.1590/s0036-46651991000400002

Cited by 32 publications

(27 citation statements)

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“…Breathing alteration together with dyspnea, tachypnea, and acute breathing insufficiency was also mentioned by Amaral et al (2) in three human patients victims of accident by Crotalus durissus terrificus. Signs appeared in the first 48 hours after the ophidic accident but the patients did not present alterations in radiographs of the thorax.…”

Section: Clinical Evaluationsupporting

confidence: 52%

“…Signs appeared in the first 48 hours after the ophidic accident but the patients did not present alterations in radiographs of the thorax. In spite of the absence of significant breathing alterations in the animals of the present study, it is necessary to emphasize that complications due to paralysis of the breathing musculature are important complications mentioned by other authors (2,12,17).…”

Section: Clinical Evaluationmentioning

confidence: 55%

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Clinical and hematological alterations in dogs during experimental envenomation with Crotalus durissus terrificus venom and treated with antiophidic serum

Nogueira¹,

Sakate²

2006

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:The present work aimed to evaluate the clinical and hematological aspects during experimental envenomation by Crotalus durissus terrificus in dogs treated with different antiophidic serum doses. Sixteen dogs were divided into two groups of eight animals each. Group I received 1mg/kg venom subcutaneously and 30mg antiophidic serum intravenously; Group II received 1mg/kg venom subcutaneously and 60mg antiophidic serum intravenously. In the clinical evaluation, we observed ataxia, moderate sedation, dilated pupils, sialorrhea, flaccid paralysis of mandibular muscles, and discreet edema at the site of venom inoculation. Evaluating red and white blood cells, we observed a decrease of hemoglobins, globular volume and erythrocytes, and an increase of plasmatic proteins, leukocytes, neutrophils, monocytes and lymphocytes. Clotting time increased and there was blood incoagulability with return to normal clotting time six hours after antiophidic serum administration. Animals treated with six antiophidic serum flasks had a faster recovery than the animals that received three serum flasks.

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Section: Clinical Evaluationsupporting

confidence: 52%

Section: Clinical Evaluationmentioning

confidence: 55%

Clinical and hematological alterations in dogs during experimental envenomation with Crotalus durissus terrificus venom and treated with antiophidic serum

Nogueira¹,

Sakate²

2006

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Dyspnea and lower respiratory and cardiac frequencies were seen, especially in animals from group VS, which are related to the crotalic venom's myotoxic and neurotoxic action. This goes along with findings from Amaral et al (1991), Nogueira & Sakate (2006) and Nogueira et al (2007).…”

Section: Discussionsupporting

confidence: 77%

“…Crotalic venom has neurotoxic (Vital-Brazil 1972, Amaral et al 1991, Jorge & Ribeiro 1992, systemic myotoxic, and nefrotoxic actions (Amaral et al 1986, Azevedo-Marques et al 1985, Castro 2006. It also changes blood clotting (Amaral et al 1988) and causes hemolysis in vitro .…”

mentioning

confidence: 99%

Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats

Floriano

Nogueira

Sakate³

et al. 2009

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Abstract:Crotalic envenomation represents the highest number of deaths when compared to other snakebite envenomations of medical interest. Crotalic venom has important characteristics such as neurotoxicity, myotoxicity, nephrotoxicity, and clotting and hemolytic action. We evaluated the clinical and laboratory aspects of Crotalus durissus terrificus experimental envenomation in Wistar rats treated with antivenom and the aqueous extract of the plant Mikania glomerata. The animals were divided into three groups: Group C (control); Group VS-venom and antivenom; Group VSM-venom, antivenom and aqueous extract of M. glomerata. Crotalic poison caused clinical and laboratory alterations in Wistar mice. Significant clinical alterations were: temperature decrease, edema in the venom inoculated member, sedation and a locomotion decrease in groups VS and VSM when compared with group C. A faster recovery from sedation was observed only for animals of group VSM when compared to VS. There was an increase in the number of leukocytes, neutrophils and creatine kinase in the VS and VSM groups, compared to group C. Wistar rats showed a high resistance to crotalic venom. Additional studies with different doses, time of treatment, different administration methods and histopathological and immunological studies are necessary to understand the action of M. glomerata in crotalic accidents. Rev. Biol. Trop. 57 (4): 929-937. Epub 2009 December 01.

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“…Acreditamos que o edema poderia passar despercebido se o local da inoculação não fosse previamente tricotomizado. Esta ausência de alterações no local da picada também foi descrita em humanos (Amaral et al 1991).…”

Section: Discussionunclassified

Aspectos clínico-patológicos e laboratoriais do envenenamento crotálico experimental em bovinos

et al. 2008

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Pesq. Vet. Bras. 28(6):261-270, junho 2008 RESUMO.-Reproduziu-se experimentalmente o envenenamento crotálico, através da inoculação, por via subcutânea, do veneno de Crotalus durissus terrificus (cascavel sul-americana) em dez bovinos mestiços. Dois animais foram utilizados como controle. O bovino que recebeu dose de 0,03mg/kg de peso corporal, morreu 7h40min após a inoculação. A dose de 0,015mg/kg causou a morte em quatro de sete bovinos inoculados, enquanto os dois animais que receberam 0,0075mg/kg adoeceram discretamente e se recuperaram. Os sintomas tiveram início entre 1h30min e 13h45min após a inoculação. A evolução oscilou entre 5h25min e 45h para os animais que morreram e entre 33h15min e 17 dias entre os animais que se recuperaram. Os principais sinais nervosos observados foram diminuição da resposta aos estímulos Crotalus poisoning was experimentally reproduced by subcutaneous inoculation of Crotalus durissus terrificus (South American rattlesnake) venom into 10 clinically healthy mixed bred 12 to 36-month-old cattle, weighing 125 to 449 kg. Two animals were used as controls. The animal that received a dose of 0.03mg/kg body weight died 7h40min after inoculation. A 0.015mg/kg dose provoked death in 4 out of 7 young oxen. Two animals given 0.0075mg/kg became slightly sick and recovered. Onset of symptoms occurred from 1h30min to 13h45min after inoculation. The clinical course varied from 5h25min to 45h for animals that died, and from 33h15min to 17 days for animals that recovered. The main nervous signs observed were diminished response to external stimuli, hypotonic reflexes, dragging of the hooves, apathy, difficulties in moving around obstacles, ocular globe paralysis, lateral and sternal decubitus, and tongue paralysis. Adipsia and sometimes petechiae in the conjunctival and vaginal mucosa were observed. A slight to moderate increase in bleeding time was noted in 6 animals, and a moderate increase in partial thromboplastin time was found in 7 others. Moderate leukocytosis with neutrophilia, relative lymphopenia, eosinopenia, and monocytosis was found. There was a significant increase in creatine kinase serum levels of a ten-fold order. No significant alterations were revealed by urinalysis. Necropsy revealed minimal edema at the inoculation site, few petechiae and equimoses in the epicardium, omentum, biliary vesicle and bladder mucosa of some animals. Histopathological examination revealed necrosis (hyalinization) of groups or isolated myocytes in different muscles examined, both near and far from the inoculation site, in all animals. The diagnosis of Crotalus poisoning and its differentiation from diseases causing paralysis and muscular necrosis in cattle in Brazil are discussed.

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Comprometimento respiratório secundário a acidente ofídico crotálico (Crotalus durissus)

Cited by 32 publications

References 4 publications

Clinical and hematological alterations in dogs during experimental envenomation with Crotalus durissus terrificus venom and treated with antiophidic serum

Clinical and hematological alterations in dogs during experimental envenomation with Crotalus durissus terrificus venom and treated with antiophidic serum

Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats

Aspectos clínico-patológicos e laboratoriais do envenenamento crotálico experimental em bovinos

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