Compromiso multisistémico en apnea obstructiva del sueño

Labarca, Gonzalo; N, Rodrigo Cruz; Descalzi, Fernando

doi:10.4067/s0034-98872014000600009

Cited by 31 publications

(10 citation statements)

References 48 publications

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“…Disturbed sleep and nocturnal altered breathing are related to disturbances of glucose metabolism. Many studies have explored the role of these factors on the variability of fasting glycemia [17] [18]. They have revealed that the respiratory and sleep disturbances that are seen due to a variety of factors have a very direct influencing effect on the glycemic control of a patient.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Poor Sleep Quality among Type 2 Diabetes Mellitus Patients on Insulin Therapy

Sathyanarayanan¹,

Benny²,

Osborn³

et al. 2015

JDM

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The aim of this study is to investigate the possible risk factors of poor sleep quality among patients with type 2 diabetes mellitus on insulin therapy. The factors considered were age, sex, body mass index (BMI), glycosylated haemoglobin (HbA1c), duration of diabetes and depression. A total of 202 diabetic patients aged 20 years or older were included in the study. The results showed that female sex and depression were independent risk factors for poor sleep quality among type 2 diabetics on insulin therapy. Findings may contribute to sleep disorder control in female patients with type 2 diabetes mellitus which has been linked to glycemic control. A. Sathyanarayanan et al. 207 activity are designed to prevent and manage diabetes and its complications. New strategies against the disease are needed. This is vital for the development of more efficient methods to counteract the progress of the disease and channelize our efforts directed at changes which most affect the disease. One component which is shown to have an impact is the relationship between diabetes and sleep quality [2]. Studies in other parts of the country have reported that short sleep duration or poor sleep quality may relate to glucose metabolism. Insulin administration was reported to be an important reason for the prevalence of sleep abnormalities. Data suggest that diabetes is associated with periodic breathing, a respiratory abnormality associated with abnormalities in the central control of ventilation, which in turn affects sleep [3].This can have many ramifications over the course and treatment of the patients who are on chronic insulin therapy. Not many studies have examined the factors associated with poor sleep quality in patients with type 2 diabetes using insulin. A recent study was conducted including 140 type 2 diabetics on insulin therapy. The possible risk factors that were considered in the study were age, sex, BMI, HbA1c, duration of diabetes and global PSQI score [4]. The results of the study showed poor sleep quality in females type 2 diabetes patients with insulin therapy. However, in this study depression was not considered which might confound the findings. In addition, many studies have reported a higher prevalence of depression among patients on insulin therapy [5]- [7]. The aim of the present study is to examine the factors associated with poor sleep quality among type 2 diabetes on insulin therapy. The factors considered were age, sex, BMI, HbA1c, duration of diabetes and depression.

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Section: Discussionmentioning

confidence: 99%

Factors Associated with Poor Sleep Quality among Type 2 Diabetes Mellitus Patients on Insulin Therapy

Sathyanarayanan¹,

Benny²,

Osborn³

et al. 2015

JDM

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“…В последние годы открыты механизмы связи СОАС с нейрокогнитивной, эндокринной, сердечно-сосудистой системами и метаболическими нарушениями. Доказано, что СОАС не просто усугубляет течение сердечной недостаточности (СН), способствует нарушениям ритма сердца, являясь предиктором возникновения и рецидива фибрилляции предсердий, но и повышает риск общей смертности вне зависимости от причин [27,28].…”

Section: влияние гэрб на течение ибсunclassified

Gastroesophageal Reflux Disease and Coronary Heart Disease: Is There a “Mutual Burden” Syndrome?

Алексеева

Пикулев

2019

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim. This review aims to generalize data on the mutual aggravating effect on the course of gastroesophageal reflux disease (GERD) and coronary heart disease (CHD).General findings. The combination of CHD and GERD is a common clinical situation. In recent years, more and more information has appeared indicating a non-accidental character of the comorbidity of both diseases. In addition to common risk factors, a number of pathophysiological mechanisms have been established that determine a pathogenetic relationship between CHD and GERD. Reflux disease contributes adversely to chronic coronary heart disease, e.g. by increasing the risk of developing myocardial infarction (MI). The co-occurrence of myocardial ischemia episodes (registered by ECG) with those of heartburn has been identified. A correlation between pathological reflux and ST segment depression has been found. A trigger role of reflux in relation to angina attacks and heart rhythm disturbances has been determined. The pro-arrhythmic effects of GERD on the myocardium are explained by an imbalance of the autonomic nervous system with a predominance of the parasympathetic tone. In turn, both stable angina and myocardial infarction contribute to a more aggressive and refractory course of reflux esophagitis (RE), thus triggering reflux symptoms.Conclusion. The comorbid course of coronary heart disease and GERD is based on complex associations; this clinical situation is characterized by a mutual burden syndrome. Given the high prevalence of a combination of both diseases, it seems relevant to develop pathogenetically substantiated approaches to the management of this category of patients.

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“…It is a common sleep disorder characterized by repetitive upper airway collapse with apnea/hypopnea and recurrent hypoxia during sleep, which results in fragmented sleep and intermittent drops in arterial blood oxygen saturation (hypoxemia) (2). The potential consequences of OSA involve multiple systems including cardiovascular, endocrine, and respiratory and neurocognitive dysfunction.…”

Section: Contextmentioning

confidence: 99%

Association Between Obstructive Sleep Apnea and Osteoporosis: A Systematic Review and Meta-Analysis

Upala

Sanguankeo

Congrete

2016

Int J Endocrinol Metab

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ContextHypoxia reduces osteoblast growth resulting in bone thinning and osteoporosis. Although obstructive sleep apnea (OSA) with recurrent hypoxia might be a contributing factor for osteoporosis development, whether OSA is a risk or protective factor for osteoporosis has not been demonstrated.ObjectivesThis systematic review and meta-analysis evaluated the association between OSA and osteoporosis using published observational studies.Data SourcesPubMed/MEDLINE and EMBASE databasesStudy SelectionWe completed a systematic review and meta-analysis of published observational studies that evaluated incidence or prevalence of osteoporosis or bone mineral density in obstructive sleep apnea compared with controls. Severity of OSA was characterized using the apnea-hypopnea index (AHI).Data ExtractionPrimary outcomes were incidence, prevalence, or odds ratio of having osteoporosis, defined as bone mineral density T-score < -2.5 SD.ResultsOf 353 articles, 344 articles were excluded, 9 underwent full-length review and data were extracted from 7 studies consisting of 113,558 patients. Finally, 3 extracted studies were included in the meta-analysis of osteoporosis. Among cohort studies, the pooled odds ratio of osteoporosis in patients with OSA was 1.92 (95% confidence interval [CI]: 1.24 - 2.97) compared with controls. Among cross-sectional studies, odds of osteoporosis was higher in controls compared with patients with OSA (OR = 0.60, 95% CI: 0.42 - 0.87). In subgroup analysis by gender and study design, in both sexes, only cohort studies had higher odds of osteoporosis compared with controls.ConclusionsThere was significant association between OSA and osteoporosis in studies with cohort design. Further prospective studies with large numbers of patients adjusted for the effects of age, sex, or BMI are required to comprehensively determine whether OSA is a risk factor for osteoporosis.

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Compromiso multisistémico en apnea obstructiva del sueño

Cited by 31 publications

References 48 publications

Factors Associated with Poor Sleep Quality among Type 2 Diabetes Mellitus Patients on Insulin Therapy

Factors Associated with Poor Sleep Quality among Type 2 Diabetes Mellitus Patients on Insulin Therapy

Gastroesophageal Reflux Disease and Coronary Heart Disease: Is There a “Mutual Burden” Syndrome?

Association Between Obstructive Sleep Apnea and Osteoporosis: A Systematic Review and Meta-Analysis

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