Compulsive habits in restless legs syndrome patients under dopaminergic treatment

Pourcher, Emmanuelle; Rémillard, Sophie; Cohen, Henrí

doi:10.1016/j.jns.2009.11.010

Cited by 57 publications

(35 citation statements)

References 28 publications

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“…In line with this assertion, pramipexole during encoding blocked the discrimination between high reward stimuli and low reward stimuli in a reward learning task (Santesso et al, 2009;Pizzagalli et al, 2008). This interpretation also fits well with reports of increases in compulsive behavior in patients with restless leg syndrome and Parkinson disease treated with pramipexole (Pourcher, Remillard, & Cohen, 2010;Weintraub et al, 2010;Aiken, 2007). It is quite possible that these patients feel the urge to perform certain maladaptive behavior because pramipexole leads to a blunting of reward contingent consolidation of adaptive behavior during sleep.…”

Section: Discussionsupporting

confidence: 73%

Dopamine D2-like Receptor Activation Wipes Out Preferential Consolidation of High over Low Reward Memories during Human Sleep

Feld

Besedovsky

Kaida

et al. 2014

Journal of Cognitive Neuroscience

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Memory formation is a selective process in which reward contingencies determine which memory is maintained and which is forgotten. Sleep plays a pivotal role in maintaining information for the long term and has been shown to specifically benefit memories that are associated with reward. Key to memory consolidation during sleep is a neuronal reactivation of newly encoded representations. However, it is unclear whether preferential consolidation of memories associated with reward requires the reactivation of dopaminergic circuitry known to mediate reward effects at encoding. In a placebo-controlled, double-blind, balanced crossover experiment, we show that the dopamine D2-like receptor agonist pramipexole given during sleep wipes out reward contingencies. Before sleep, 16 men learned 160 pictures of landscapes and interiors that were associated with high or low rewards, if they were identified between new stimuli at retrieval 24 hr later. In the placebo condition, the participants retained significantly more pictures that promised a high reward. In the pramipexole condition, this difference was wiped out, and performance for the low reward pictures was as high as that for high reward pictures. Pramipexole did not generally enhance memory consolidation probably because of the fact that the dopaminergic agonist concurrently suppressed both SWS and REM sleep. These results are consistent with the concept that preferential consolidation of reward-associated memories relies on hippocampus-driven reactivation within the dopaminergic reward system during sleep, whereby during sleep reward contingencies are fed back to the hippocampus to strengthen specific memories, possibly, through dopaminergic facilitation of long-term potentiation.

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Section: Discussionsupporting

confidence: 73%

Dopamine D2-like Receptor Activation Wipes Out Preferential Consolidation of High over Low Reward Memories during Human Sleep

Feld

Besedovsky

Kaida

et al. 2014

Journal of Cognitive Neuroscience

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“…The estimated prevalence of ICDs among RLS patients on dopamine agonist treatment has varied from 5% to 17%. [21][22][23][24] In one of the few controlled studies on the topic, Cornelius and colleagues 21 found that RLS patients on dopaminergic treatment had a 17% prevalence of ICDs compared with 6% in a control group with obstructive sleep apnea (OSA) and 8% in a group of RLS patients not receiving dopamine agonists, a difference that was statistically significant only for the OSA control group. Factors that have been associated with increased numerical likelihood of developing ICDs on dopamine agonist include higher dose of dopamine agonist, young age at RLS onset, family history of gambling disorders, and female gender.…”

Section: Medications Used To Treat Restless Legs Syndromementioning

confidence: 99%

Restless Legs Syndrome and Psychiatric Disorders

Mackie

Winkelman

2015

Sleep Medicine Clinics

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“…Sleep disturbances, including sleep fragmentation and daytime sleepiness, are more common in PD patients with ICDs than PD alone and healthy controls [9]. Similar patterns of sleep disturbance have been linked to impulsive behaviour in other related disorders such as Attention Deficit/Hyperactivity Disorder (ADHD) and restless legs syndrome (RLS) [10,11], both of which have been associated with low serum levels of the iron storage protein, ferritin [12,13]. Moreover, in a study of children with ADHD, Oner and colleagues (2012) identified a relationship between serum ferritin and hyperactivity scores [14], presenting a possible marker for broader impulse control conditions.…”

Section: Introductionmentioning

confidence: 99%

Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients

Anderton¹

2017

AJPN

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Impulse control disorders (ICDs) occur in a subset of Parkinson's disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk. Sleep disturbances are more common in patients with an ICD. Serum ferritin levels have been associated with PD disease stage and progression, but have not previously been associated with impulsivity levels. The objective of this study was to determine if serum ferritin levels and sleep disturbance are associated with high traits of impulsivity and ICD in a cohort of PD patients attending a movement disorders clinic. This study assessed impulsiveness in 87 PD patients using the Barratt Impulsiveness Scale. Severity of sleep disturbance was determined using the sleep-related items of the MDS-UPDRS. Serum ferritin, iron and transferrin levels were measured in patients, as well as 36 age-matched healthy controls. Serum ferritin levels were significantly elevated in male PD patients in the high impulsivity group compared to patients in the low (p=.022) and normal range groups (p=.024) and showed a linear increase across the three groups. Sleep disturbance also demonstrated a linear trend, which was most severe in the high impulsivity group (p=.030). A subgroup of 11 male PD patients who fulfilled the DSM-5 criteria for an ICD had significantly higher ferritin levels and more severe sleep disturbance when compared with the remaining male PD cohort. Serum ferritin levels and sleep disturbance severity are highlighted as potential markers for abnormal impulsivity and ICD in PD patients.

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Compulsive habits in restless legs syndrome patients under dopaminergic treatment

Cited by 57 publications

References 28 publications

Dopamine D2-like Receptor Activation Wipes Out Preferential Consolidation of High over Low Reward Memories during Human Sleep

Dopamine D2-like Receptor Activation Wipes Out Preferential Consolidation of High over Low Reward Memories during Human Sleep

Restless Legs Syndrome and Psychiatric Disorders

Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients

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