2019
DOI: 10.3389/fnbeh.2019.00070
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Compulsivity in Alcohol Use Disorder and Obsessive Compulsive Disorder: Implications for Neuromodulation

Abstract: Alcohol use Disorder (AUD) is one of the leading causes of morbidity and mortality worldwide. The progression of the disorder is associated with the development of compulsive alcohol use, which in turn contributes to the high relapse rate and poor longer term functioning reported in most patients, even with treatment. While the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines AUD by a cluster of symptoms, parsing its heterogeneous phenotype by domains of behavior such as compulsivity may b… Show more

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Cited by 25 publications
(13 citation statements)
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References 207 publications
(255 reference statements)
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“…Alcohol interacts with two membranes receptor: GABA A and NMDA ion channel receptors, which indeed causes the enhancement of the inhibitory effect of GABA A and antagonizes the excitatory effect of glutamate. In the case of the brain reward system, the dopaminergic, serotonergic and opioid system is also well affected by the drugs [2]. As mentioned in the review, noradrenergic, neuronal nicotine acetylcholine receptors and cannabinoid systems also plays a significant role in the neurobiology of alcohol interactions.…”
Section: Discussionmentioning
confidence: 97%
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“…Alcohol interacts with two membranes receptor: GABA A and NMDA ion channel receptors, which indeed causes the enhancement of the inhibitory effect of GABA A and antagonizes the excitatory effect of glutamate. In the case of the brain reward system, the dopaminergic, serotonergic and opioid system is also well affected by the drugs [2]. As mentioned in the review, noradrenergic, neuronal nicotine acetylcholine receptors and cannabinoid systems also plays a significant role in the neurobiology of alcohol interactions.…”
Section: Discussionmentioning
confidence: 97%
“…The curiosity of research scientists, with their organized study, will gather the needs for the pharmacological treatment for AUD. The heterogeneity of AUD patients and the complex aetiology of the disease and even different patterns of consumption, onset of drinking and drinking behaviour have involved in the pharmacotherapy [2]. For example, acamprosate shows greater efficiency in promoting naltrexone efficacy, and even showed a more significant effect in a patients who had already undergone detoxification [76].…”
Section: Discussionmentioning
confidence: 99%
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“…Alcohol addiction, diagnosed via AUD, can be seen as "an aberrant form of learning, where alcohol exposure leads in time to alteration in the neurocircuitry underlying stress response, reward and cognitive functioning, all of which ultimately leads to compulsive substance use" (reviewed in " [56]"). Therefore both regularity and stress can play a role in the development of addictions.…”
Section: Do Young Swiss Men Mature Out Of Problematic Au?mentioning
confidence: 99%
“…However, we also hypothesized that these groups (OCD and AUD patients) would not differ in terms of habit scores. 30 Furthermore, regardless of their diagnostic labels, we predicted that it would be possible to identify more homogeneous clusters of patients based on their responses of HRFS and that these subgroups would include different proportions of OCD and AUD patients. In other words, OCD and AUD patients would perform their repetitive behaviors because of shared emotional states.…”
Section: Introductionmentioning
confidence: 99%