COMPUTATIONAL ANALYSIS OF BIOACTIVE COMPOUNDS Piper crocatum AS INHIBITORS OF ACETYLCHOLINESTERASE v1

Abstract

This study aims to determine the inhibition of natural compounds P. crocatum against AChE enzyme activity. Inhibition of natural compounds of P. crocatum was analyzed by combining virtual screening and molecular docking methods with two different software, namely Autodock Tools 1.5.6 and YASARA Structure. This method is expected to improve the ability to identify potential natural compounds contained in betel leaf as AD drug candidates with AChE inhibition mechanism. A total of 21 natural compounds from three red betel leaf extract fractions (water fraction, ethyl acetate, and n-hexane) were analyzed for their binding affinity energy to AChE by virtual screening along with 664 active compounds known to have AChE inhibitory activity based on the DUD-E database to identify the potential of natural compounds for each fraction of red betel leaf (P. crocatum) inhibits AChE activity

œCaring Snake & Ladder Learning Media Development For 2nd Year Students™ Competence In Reading Aloud At Mekarsari 03 Elementary School

“…In other words, Nur'aini (2017) stated that the media acts as a medium for communication during learning. According to Safithri & Rukmi (2021), the use of media in learning practices can boost students' motivation and interest in learning, encourage their curiosity, and create a fun learning environment so that they can more easily accomplish their academic objectives. Based on these viewpoints, it can be said that learning media is a tool that facilitates communication in learning so that information or learning messages can be well received to support the achievement of learning objectives.…”

“…According to Lufianah (2018), Snakes and Ladders is one of the games that may be utilized as media in teaching and learning activities, including learning to read. Snake and ladder media falls within the category of visual media, which is defined by Safithri & Rukmi (2021), as media that can be seen by the senses of sight and has pictures in it. The Snakes and Ladders board is divided into several small plots, there are pictures of "snakes" or "ladders" that can connect with other plots.…”