Computational Analysis Of Potential Key Genes Associated With Dopamine Neurotransmission In Pheochromocytoma And Paraganglioma

Abstract

P heochromocytoma and Paraganglioma (PCPG) are rare chromaffin cell tumors that produce catecholamines (CA) and present a therapeutic and diagnostic challenge, and are associated with severe morbidity when non-diagnostic [1,2]. Pheochromocytomas and Paragangliomas are originated from adrenal tissues or extra-adrenal parasympathetic or sympathetic paraganglia, respectively [2]. PCPG produce and secrete CA in the neuroendocrine system. PCPG may lead to the elevation of blood pressure and subsequently damage of target organs such as the brain, heart, and kidney. The symptoms of PCPG include palpitations, hypertension, headache, anxiety, and profuse sweating. Furthermore, PCPG may lead to metabolic disorders that are associated with insulin and blood sugar, therefore endanger the life of patients [3,4].