Computational analysis on the level of miRNA-mediated target mRNA degradation

Abstract

To investigate the influence of miRNAs on target gene at transcription levels, we have systematically analyzed the expression profiles by a regression method. The results indicated that the down-regulation level of target mRNA is determined by multiple factors including the length and secondary structure of target mRNA, the structural accessibility of the target site and so on. Furthermore, by comparison of different miRNAs, the results indicated that, in animals, all miRNAs regulate their targets in a similar way.

Research on Network Knowledge Management Mode

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