Computational and experimental studies of electrohydrodynamic atomization for pharmaceutical particle fabrication

Rezvanpour, Alireza; Lim, Ee Peng; Wang, Chi-Hwa

doi:10.1002/aic.13727

Cited by 10 publications

(6 citation statements)

References 28 publications

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“…Deposition of aerosol particles for producing nano-structured materials has been widely used in several aspects, such as biology (Kim et al, 2008), microelectronics (Deng & Gomez, 2011), biomolecular technology (Ranganath et al, 2011), environmental health applications (Jung et al, 2011), and pharmaceutical particle fabrication (Rezvanpour et al, 2012). Even though the relationship between the conditions of the substrate and the deposition mechanism of the charged aerosol particles is also important, there are few uncertainties about this topic.…”

Section: Introductionmentioning

confidence: 99%

Area-selective deposition of charged particles derived from colloidal aerosol droplets on a surface with different hydrophilic levels

Kusdianto

Gen

Lenggoro

2014

Journal of Aerosol Science

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a b s t r a c tThe effect of chemical treatment of a metallic substrate on the deposition behavior of charged aerosol particles derived from spraying droplets was investigated. A single substrate with areas having different hydrophilic levels was prepared as target surface. The treated (i.e., higher hydrophilic level) area, measured using a surface potential meter, showed a higher negative potential. A numerical simulation predicted that positively charged aerosol particles tended to approach and were subsequently immobilized on the high hydrophilic area. The area with higher hydrophilicity could collect particles with higher number concentration (density) than the other areas. The relationships were demonstrated in (i) the electrostatic surface potential, (ii) the hydrophilicity of surface, and (iii) the enhancement of adhesive force between the deposited particles and the surface.

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Section: Introductionmentioning

confidence: 99%

Area-selective deposition of charged particles derived from colloidal aerosol droplets on a surface with different hydrophilic levels

Kusdianto

Gen

Lenggoro

2014

Journal of Aerosol Science

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“…Many efforts have been made by scholars around the world to improve the atomizing performance of spray nozzles in the past decades, such as designing nozzle structures [10,11], innovating atomizing methods [12,13], and optimizing operating conditions [14,15]. Presently, it is believed that fine and uniform droplet mists can be obtained easily by the twin-fluid nozzle atomizing technology combined with external forces, and this was demonstrated to be a promising method [12,16].…”

Section: Introductionmentioning

confidence: 99%

Influence of Self-excited Vibrating Cavity Structure on Droplet Diameter Characteristics of Twin-fluid Nozzle

Chen

Gao

et al. 2018

Chin. J. Mech. Eng.

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It is a great challenge to find effective atomizing technology for reducing industrial pollution; the twin-fluid atomizing nozzle has drawn great attention in this field recently. Current studies on twin-fluid nozzles mainly focus on droplet breakup and single droplet characteristics. Research relating to the influences of structural parameters on the droplet diameter characteristics in the flow field is scarcely available. In this paper, the influence of a self-excited vibrating cavity structure on droplet diameter characteristics was investigated. Twin-fluid atomizing tests were performed by a self-built open atomizing test bench, which was based on a phase Doppler particle analyzer (PDPA). The atomizing flow field of the twin-fluid nozzle with a self-excited vibrating cavity and its absence were tested and analyzed. Then the atomizing flow field of the twin-fluid nozzle with different self-excited vibrating cavity structures was investigated. The experimental results show that the structural parameters of the self-excited vibrating cavity had a great effect on the breakup of large droplets. The Sauter mean diameter (SMD) increased with the increase of orifice diameter or orifice depth. Moreover, a smaller orifice diameter or orifice depth was beneficial to enhancing the turbulence around the outlet of nozzle and decreasing the SMD. The atomizing performance was better when the orifice diameter was 2.0 mm or the orifice depth was 1.5 mm. Furthermore, the SMD increased first and then decreased with the increase of the distance between the nozzle outlet and self-excited vibrating cavity, and the SMD of more than half the atomizing flow field was under 35 μm when the distance was 5.0 mm. In addition, with the increase of axial and radial distance from the nozzle outlet, the SMD and arithmetic mean diameter (AMD) tend to increase. The research results provide some design parameters for the twin-fluid nozzle, and the experimental results could serve as a beneficial supplement to the twin-fluid nozzle study.

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“…In addition to experimental studies, significant efforts have also been made on the analytical and numerical studies of EHDA process. However, most of the simulation and modelling works are based on single‐axial EHDA . For instance, one of the pioneering works is the numerical cone‐shape model proposed by Hartman who coupled Navier‐Stokes equation with electric tangential and normal stresses to track the evolution of the gas‐liquid interface.…”

Section: Introductionmentioning

confidence: 99%

“…Forbes et al presented a better solution to resolve the charge transport problem on the air‐liquid interface by employing charge continuity equation. Theoretical works involving both computational fluid dynamic (CFD) simulation and scaling analysis were also performed to investigate the EHDA process in a designed chamber for particle collection …”

Section: Introductionmentioning

confidence: 99%

“…Therefore, in addition to the critical parameters such as electrical conductivity, viscosity, dielectric constant, flow rate, and voltage in EHDA process, additional parameters such as interfacial tension, flow rates of liquids, and the nozzle configuration would also affect the outcome of the CEHDA process. Existing models based on single‐axial EHDA cannot be directly employed to the CEHDA system. The reported theoretical studies on CEHDA are mainly based on scaling laws or instability analysis which involve multiple assumptions and simplifications.…”

Section: Introductionmentioning

confidence: 99%

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Computational study of core‐shell droplet formation in coaxial electrohydrodynamic atomization process

et al. 2016

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In this study, a computational fluid dynamic (CFD) model was developed to simulate the liquid cone-jet and core-shell droplet formation in the Coaxial Electrohydrodynamic Atomization (CEHDA) process. Validation experiments were conducted using poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) solutions as core and shell materials, respectively. Good agreement was obtained between experimental results and simulation predictions in terms of both particle size and core-shell structure. Investigation of interfacial tension between core and shell fluids showed that a stable compound cone-jet and droplet can be easily formed using miscible or partially miscible liquids compared with immiscible liquids with higher interfacial tension. It was also found that the nozzle tip configuration has significant effects on droplet production due to differences in fluid motion. The results also showed that the productivity of the CEHDA process, i.e. slow production of core-shell microparticles due to low flow rates, could be enhanced by using optimal cone-shaped nozzle configuration. Overall, this computational model provided a means of designing and optimizing CEHDA processes for large-scale core-shell microparticle fabrication in pharmaceutical application, such as selections of materials and nozzle Particle Technology and FluidizationAIChE Journal

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Computational and experimental studies of electrohydrodynamic atomization for pharmaceutical particle fabrication

Cited by 10 publications

References 28 publications

Area-selective deposition of charged particles derived from colloidal aerosol droplets on a surface with different hydrophilic levels

Area-selective deposition of charged particles derived from colloidal aerosol droplets on a surface with different hydrophilic levels

Influence of Self-excited Vibrating Cavity Structure on Droplet Diameter Characteristics of Twin-fluid Nozzle

Computational study of core‐shell droplet formation in coaxial electrohydrodynamic atomization process

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