Computational and Pharmacological Studies on the Antioxidant, Thrombolytic, Anti-Inflammatory, and Analgesic Activity of Molineria capitulata

Abstract

Molineria capitulata is an ornamental plant that has traditionally been used to treat several chronic diseases. The present study was designed to examine the antioxidant, cytotoxic, thrombolytic, anti-inflammatory, and analgesic activities of a methanolic extract of M. capitulata leaves (MEMC) using both experimental and computational models. Previously established protocols were used to perform qualitative and quantitative phytochemical screening in MEMC. A computational study, including molecular docking and ADME/T analyses, was performed. The quantitative phytochemical analysis revealed the total phenolic and flavonoid contents as 148.67 and 24 mg/g, respectively. Antioxidant activity was assessed by examining the reducing power of MEMC, resulting in absorbance of 1.87 at 400 µg/mL, demonstrating a strong reduction capacity. The extract exhibited significant protection against blood clotting and showed the highest protein denaturation inhibition at 500 µg/mL. In both the acetic acid-induced writhing and formalin-induced paw-licking models, MEMC resulted in significant potential pain inhibition in mice. In the computational analysis, 4-hydroxybenzaldehyde, orcinol glucoside, curcapital, crassifogenin C, and 2,6-dimethoxy-benzoic acid displayed a strong predictive binding affinity against the respective receptors. These findings indicated that M. capitulata possesses significant pharmacological activities to an extent supported by computational studies.

Characterizing the Antitumor Effect of Coptis chinensis and Mume Fructus against Colorectal Cancer Based on Pharmacological Analysis

“…Green Tea Polyphenols are involved in immunoregulation and have antibacterial, antioxidant and anti-inflammatory activities, and it is used against diseases caused by the coronavirus [ 23 ]. The methanol extracts of Molineria capitulata have antioxidization, cytotoxicity, thrombolysis, anti-inflammation, and analgesic properties [ 24 ]. Last but not least, cannabinoids can be used as a source of new functional food ingredients and nutraceuticals, which are effective in treating and preventing gastrointestinal diseases [ 25 ].…”

In Vitro Antilipidic and Antithrombotic Activities of Plectranthus glandulosus (Lamiaceae) Leaves Extracts and Fractions

“…Flavonoids present in extracts, and fractions might be responsible for the thrombolytic activity observed in this study [ 22 ]. Also, alkaloids, tannins, and saponins, which were identified in the plant in previous studies [ 28 – 31 ], are involved in thrombolytic activities [ 23 ].…”

“…Dietary polyphenols may also suppress the growth of adipose tissue through their antiangiogenic activity and by modulating adipocyte metabolism [ 21 ], as well as thrombolytic activity by dissolving blood clots [ 22 ]. Moreover, alkaloids, tannins, and saponins are involved in thrombolytic activity [ 23 ].…”

Efficacy and Safety of Transcutaneous Electrical Acupoint Stimulation (TEAS) for Postoperative Pain in Laparoscopy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…In addition, pharmacological studies have shown that some medicinal plants are safe natural analgesics and have potential therapeutic advantages. For example, Molineria capitulata and Spirulina platensis have anti-inflammatory, antioxidant, and analgesic effects [ 15 , 16 ]. Bromelain is a natural drug to alleviate the symptoms of arthritis (including joint pain and stiffness) [ 17 ].…”