Computational cardiac electrophysiology is moving towards translation medicine

Severi, Stefano; Rodríguez, Blanca; Zaza, Antonio

doi:10.1093/europace/euu085

Cited by 4 publications

(2 citation statements)

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“…Advances in computational cardiac electrophysiology were recently illustrated in two dedicated special issues of Europace 2014 . 4,5 Furthermore, new initiatives such as the Comprehensive in vitro Proarrhythmia Assay (CiPA) launched by the United States Food and Drug Administration (FDA) recognize the potential of human-based in silico and in vitro approaches as a new paradigm for drug safety assessment. 6 …”

Section: Motivationmentioning

confidence: 99%

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

et al. 2015

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Both biomedical research and clinical practice rely on complex datasets for the physiological and genetic characterization of human hearts in health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed computational methods in cardiovascular medicine and science for analysis, integration and prediction. This paper describes a Workshop on Computational Cardiovascular Science that created an international, interdisciplinary and inter-sectorial forum to define the next steps for a human-based approach to disease supported by computational methodologies. The main ideas highlighted were (i) a shift towards human-based methodologies, spurred by advances in new in silico, in vivo, in vitro, and ex vivo techniques and the increasing acknowledgement of the limitations of animal models. (ii) Computational approaches complement, expand, bridge, and integrate in vitro, in vivo, and ex vivo experimental and clinical data and methods, and as such they are an integral part of human-based methodologies in pharmacology and medicine. (iii) The effective implementation of multi- and interdisciplinary approaches, teams, and training combining and integrating computational methods with experimental and clinical approaches across academia, industry, and healthcare settings is a priority. (iv) The human-based cross-disciplinary approach requires experts in specific methodologies and domains, who also have the capacity to communicate and collaborate across disciplines and cross-sector environments. (v) This new translational domain for human-based cardiology and pharmacology requires new partnerships supported financially and institutionally across sectors. Institutional, organizational, and social barriers must be identified, understood and overcome in each specific setting.

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Section: Motivationmentioning

confidence: 99%

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

et al. 2015

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“…In order to overcome the current clinical lackings and become an effective supportive tool, computational hemodynamics has recently started to be adopted from a translational medicine perspective [44,45]. In particular, lumped-parameter approaches have been recently exploited to simulate AF conditions and evaluate the global hemodynamic response [42,43,3].…”

Section: Introductionmentioning

confidence: 99%

Effects of atrial fibrillation on the arterial fluid dynamics: a modelling perspective

2018

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Atrial fibrillation (AF) is the most common form of arrhythmia with accelerated and irregular heart rate (HR), leading to both heart failure and stroke and being responsible for an increase in cardiovascular morbidity and mortality. In spite of its importance, the direct effects of AF on the arterial hemodynamic patterns are not completely known to date. Based on a multiscale modelling approach, the proposed work investigates the effects of AF on the local arterial fluid dynamics. AF and normal sinus rhythm (NSR) conditions are simulated extracting 2000 RR heartbeats and comparing the most relevant cardiac and vascular parameters at the same HR (75 bpm). Present outcomes evidence that the arterial system is not able to completely absorb the AF-induced variability, which can be even amplified towards the peripheral circulation. AF is also able to locally alter the wave dynamics, by modifying the interplay between forward and backward signals. The sole heart rhythm variation (i.e., from NSR to AF) promotes an alteration of the regular dynamics at the arterial level which, in terms of pressure and peripheral perfusion, suggests a modification of the physiological phenomena ruled by periodicity (e.g., regular organ perfusion)and a possible vascular dysfunction due to the prolonged exposure to irregular and extreme values. The present study represents a first modeling approach to characterize the variability of arterial hemodynamics in presence of AF, which surely deserves further clinical investigation.

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Personalized Computational Modeling for the Treatment of Cardiac Arrhythmias

Weinberg

2016

The Digital Patient

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Computational cardiac electrophysiology is moving towards translation medicine

Cited by 4 publications

References 10 publications

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Effects of atrial fibrillation on the arterial fluid dynamics: a modelling perspective

Personalized Computational Modeling for the Treatment of Cardiac Arrhythmias

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