Computational Challenges in Deciphering Genomic Structures of Bacteria

Abstract

This article addresses how the functionalities of the cellular machinery of a bacterium might have constrained the genomic arrangement of its genes during evolution and how we can study such problems using computational approaches, taking full advantage of the rapidly increasing pool of the sequenced bacterial genomes, potentially leading to a much improved understanding of why a bacterial genome is organized in the way it is. This article discusses a number of challenging computational problems in elucidating the genomic structures at multiple levels and the information that is encoded through these genomic structures, gearing towards the ultimate understanding of the governing rules of bacterial genome organization.

A Modular Database Architecture Enabled to Comparative Sequence Analysis

“…Furthermore, sequence alignments and gene trees resulting from the comparative analysis can be accessed. Computational challenges in the field of comparative analyses have been overcome [39]. The developed tools have helped in elucidating the genomic structures of a multiple levels of prokaryotes [6], leading to a much improved understanding of why a bacterial genome is organized in the way it is.…”