This article aims to better understand the effect that Active Flow Control (AFC) drag reduction systems have in the aerodynamic profile of a Ground Transportation System (GTS) model when asymmetric blowing configurations are allowed. To that end, this study relies in the use of Reynolds-Averaged Navier-Stokes (RANS) to quantify the system effectiveness by simulating the flow over the vehicle and computing drag and overall power consumption. In this study the top, bottom, and the side jets blowing strengths are varied separately to quantify the effect of each component in the overall aerodynamic behavior of the vehicle. The wake structure and back pressure distribution for each blowing configuration have been analyzed, and the flow structure changes, due to asymmetric blowing, have been analyzed and turned into guidelines for future design studies of AFC drag reduction systems. This article shows that by allowing asymmetric blowing in the back of the GTS model, drag and power consumption have been reduced by 19% and 16% respectively.