Stripe patterns are ubiquitous in nature and everyday life. While the synthesis of these patterns has been thoroughly studied in the literature, their potential to control the mechanics of structured materials remains largely unexplored. In this work, we introduce Differentiable Stripe Patterns---a computational approach for automated design of physical surfaces structured with stripe-shaped bi-material distributions. Our method builds on the work by Knöppel and colleagues [2015] for generating globally-continuous and equally-spaced stripe patterns. To unlock the full potential of this design space, we propose a gradient-based optimization tool to automatically compute stripe patterns that best approximate macromechanical performance goals. Specifically, we propose a computational model that combines solid shell finite elements with XFEM for accurate and fully-differentiable modeling of elastic bi-material surfaces. To resolve non-uniqueness problems in the original method, we furthermore propose a robust formulation that yields unique and differentiable stripe patterns. We combine these components with equilibrium state derivatives into an end-to-end differentiable pipeline that enables inverse design of mechanical stripe patterns. We demonstrate our method on a diverse set of examples that illustrate the potential of stripe patterns as a design space for structured materials. Our simulation results are experimentally validated on physical prototypes.