Computational efforts to identify natural occurring compounds from phyllanthus niruri that target hepatitis B viral infections: DFT, docking and dynamics simulation study

Activity and potential of Phyllantus niruri L. and Phyllantus urinaria L. as Hepatitis B virus inhibitors: A narrative review of the SANRA protocol

“…The HepG2 cell line 2.2.15 is employed as a test medium through the process of destabilization, which results in the amplification of the degradation of proteins into polypeptides and the modification of the activity and properties of HBeAg. Therefore, HBV is impaired in its normal functioning, making it a valuable and productive candidate as a viral blocking agent [18,30,50,51,53,61].…”

“…Previous studies have shown that compounds found in the roots, stems, leaves, and flowers of these two species effectively inhibit the life cycle of the hepatitis virus. Therefore, their antiviral effects can be developed in the future [5,[17][18][19]. Arbab et al [20] identified and evaluated the antiviral activity of 60 plant species, concluding that the compounds contained in P. niruri L. and P. urinaria L. were active as HBV inhibitor agents [21].…”

Construction of a screening and evaluation system for anti-hepatitis B virus drugs based on quadratic exponential smoothing model

“…Hepatitis B vaccination is essential for the effective control of HBV transmission, and China has implemented a mandatory planned immunization for newborns who are vaccinated against hepatitis B at birth. The protective effect of vaccination with antibody response generally lasts for at least twelve years, and anti-HB monitoring can be performed in highrisk groups, with booster immunization if necessary [6][7][8]. Antiviral therapy is the fundamental treatment for chronic hepatitis B, while hepatitis B carriers do not need antiviral therapy even if their HBV-DNA levels are high as long as their liver function is normal [9][10].…”