Many high-rise buildings have semi-enclosed landscaped spaces, which act as design elements to improve the social and environmental aspects of the building. Designs such as skygardens are open to outdoor airflow and allow occupants to observe the city skyline from a height. Due to their often high location, they are subjected to strong wind speeds and extreme environmental conditions. The current study investigates the effects of three common wind buffers (railing, hedges, and trees) located at a height of 92 m on the performance of a skygarden, in terms of occupants’ wind comfort. Computational fluid dynamics (CFD) simulations were carried out using the realisable k-epsilon method, where the vegetation was modelled as a porous zone with cooling capacity. The computational modelling of the high-rise building and vegetation were validated using previous works. The quality class (QC) of the Lawson comfort criteria was used for the evaluation of the wind comfort across the skygarden. The results indicate that, although the three wind buffers offer varying levels of wind reduction in the skygarden, the overall wind conditions generated are suitable for occupancy. Furthermore, vegetation is also able to offer slight temperature reductions in its wake. The right combination and dimension of these elements can greatly assist in generating aero-thermal comfort across skygardens.