Computational FEM Model,<i>Phantom</i>and<i>Ex Vivo</i>Swine Breast Validation of an Optimized Double-Slot Microcoaxial Antenna Designed for Minimally Invasive Breast Tumor Ablation: Theoretical and Experimental Comparison of Temperature, Size of Lesion, and SWR, Preliminary Data

Guerrero, Geshel David; Rubio, Mario Francisco Jesús Cepeda; Jacquez, José I. Hernández; Hernández, Arturo Vera; Salas, Lorenzo Leija; Perezgasga, Francisco Valdés; García, Francisco Flores

doi:10.1155/2017/1562869

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…Additionally, the specific absorption rate [ 3 ] defines the power absorbed by the tissues. This factor is useful in analyzing the radiation of nonionizing frequencies as shown below:

…”

Section: Methodsmentioning

confidence: 99%

“…Previous research demonstrated the possibility of performing microwave ablation therapy for breast carcinoma tissue [ 3 ]. Given the nature of the procedure (i.e., minimally invasive and replicable), it is important to explore possible applications for different types of lesions, such as premalignant lesions.…”

Section: Methodsmentioning

confidence: 99%

“…However, these treatments are associated with important physical and emotional side effects [ 2 ]. Therefore, the application of different technologies (e.g., tissue ablation through the emission of electromagnetic waves, chemical or thermal means) has been investigated [ 3 ]. The one that has had the most promising results in multiple tissues such as the bone and liver is microwave ablation performed by needle applicators.…”

Section: Introductionmentioning

confidence: 99%

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Computational FEM Model and Phantom Validation of Microwave Ablation for Segmental Microcalcifications in Breasts Using a Coaxial Double-Slot Antenna

Félix

Guerrero

Rubio

et al. 2021

BioMed Research International

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Introduction. Cancer is the second leading cause of death worldwide. Breast cancer is the second most common cause of cancer-related mortality, accounting for 11.6% of the total number of deaths. The main treatments for this disease are surgical removal of the tumor, radiotherapy, and chemotherapy. Recently, different minimally invasive technologies have been applied (e.g., emission of electromagnetic waves, thermal and chemical means) to overcome the important side effects of these treatment modalities. The objective of this study was to develop and evaluate a predictive computational model of microwave ablation. Materials and Methods. The predictive computational model of microwave ablation was constructed by means of a dual-slot coaxial antenna. The model was compared with an experiment performed using a breast phantom, which emulates the dielectric properties of breast tissue with segmental microcalcifications. The standing wave ratio (SWR) was obtained for both methods to make a comparison and determine the feasibility of applying electromagnetic ablation to premalignant lesions in breasts. Specifically, for the analysis of segmental microcalcifications, a breast phantom with segmental microcalcifications was developed and two computational models were performed under the same conditions (except for blood perfusion, which was excluded in one of the models). Results. The SWR was obtained by triplicate experiments in the phantom, and the measurements had a difference of 0.191 between the minimum and maximum SWR values, implying a change of power reflection of 0.8%. The average of the three measurements was compared with the simulation that did not consider blood perfusion. The comparison yielded a change of 0.104, representing a 0.2% change in power reflection. Discussion. Both experimentation in phantom and simulations demonstrated that ablation therapy can be performed using this antenna. However, an additional optimization procedure is warranted to increase the efficiency of the antenna.

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“…Additionally, the specific absorption rate [ 3 ] defines the power absorbed by the tissues. This factor is useful in analyzing the radiation of nonionizing frequencies as shown below:

…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Computational FEM Model and Phantom Validation of Microwave Ablation for Segmental Microcalcifications in Breasts Using a Coaxial Double-Slot Antenna

Félix

Guerrero

Rubio

et al. 2021

BioMed Research International

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“…The electrical and thermal properties are assigned to the skin, gland, and tumor. For the simple model, those values were based on the built-in material library in the CST and the previous studies [16][17][18]. Detailed properties are illustrated in Table 1.…”

Section: Materials Propertiesmentioning

confidence: 99%

Utilizing a Floating Sleeve Antenna for Interstitial Microwave Hyperthermia Treatment of Superficial and Deep-seated Breast Tumors

Eltigani,

Ahmed

2023

Preprint

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Purpose: Breast cancer is a leading cause of mortality among women worldwide. While chemotherapy and radiotherapy are commonly used treatment modalities, they have several side effects that can negatively impact the patient. In this study, we explore the application of a floating sleeve antenna for interstitial microwave hyperthermia for breast tumors. Method: Two distinct 3D breast models were employed: a simplified semi-spherical and a highly detailed anatomical model. Both models featured superficial and deep-seated tumors. The floating sleeve antenna was inserted into the breast models, and simulations were con-ducted to assess the specific absorption rate (SAR) and temperature distribution. Results: In the simple model, the superficial tumor reached a maximum temperature of 50.7 ºC, while the deep-seated tumor maintained a uniform temperature of 48.9 ºC. In contrast, the realistic model achieved a maximum temperature of 46.2 ºC for the superficial tumor and 41.47 ºC for the deep-seated tumor within the same 15-minute treatment period. These results demonstrate the ability of the antenna to attain the desired hyperthermia temperatures (above 39 °C to 45 °C). Conclusion: microwave hyperthermia using a floating sleeve antenna has the potential to be an effective and safe alternative treatment for breast cancer with minimal side effects

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“…Microwave ablation therapy has been proven effective on bone and liver cancer with promising results by coaxial antenna needle applicators [4,5], and many antenna models have been studied to optimize the treatment [6]. Previous works, such as [7], compared a microwave ablation Finite Element Method simulation of an in-silico homogenous breast with carcinoma ductal in-situ tissue model with an ex-vivo swine breast and carcinoma ductal in-situ phantom tissue, obtaining better temperatures, greater ablation zone, and coupling between the biological tissue and antenna with the validation phantom tissue. Another interesting work validated the simulation of microwave ablation of segmental microcalcifications found in breast tissues, obtaining a better coupling with a phantom tissue, demonstrating that this procedure can be applied to such lesion types [8].…”

Section: Introductionmentioning

confidence: 99%

In-Silico Comparison of Thermal Microwave Ablation Therapy for Segmental Microcalcifications in Homogenous and Heterogenous Breast Tissue Models

García,

Rubio,

López

et al. 2023

Preprint

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Among women across the world, breast cancer is the number one cause of death since 2020. Some of the main treatments against this affection represent severe physiological and aesthetic adverse effects. To reduce these side effects, many minimally invasive treatments have been researched. One of these many techniques is ablation therapy by emission of electromagnetic waves, chemical or cryogenic means. This work aims to compare the computational modelling of microwave ablation therapy in heterogeneous (volume of tissue driven) and homogeneous (density of tissue driven) breasts that present segmental microcalcifications. The main objective is to compare the differences between thermal, reflection parameters and power reflection between the two model simulations. For the application of microwave radiation, a coaxial dual-slot antenna model, at an operating frequency of 2.45 GHz, and 12 W of input power was used. The simulations of each homogeneous model yielded a power reflection below 17% and reached the desired 50°C ablation temperatures below 250s therapy time. Specifically, the Low-Density model got an SWR of 1.78, a -11.023 dB S11and a power reflection of 7.913%. The heterogenous model simulations got a power reflection above 18% and reached the desired 50°C ablation temperatures below 250s therapy time. Where each desired parameter yielded closed results, being the best the High-Density model with respect to a SWR of 2.4897, and 18.223% of reflected power. The data shows that it is best to consider the variation in dielectric properties of a homogenous breast model rather than the segmentation of the tissues. Therefore, more research is required for the optimization of the antenna for each homogenous breast density considering other malignant tissues.

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Computational FEM Model,PhantomandEx VivoSwine Breast Validation of an Optimized Double-Slot Microcoaxial Antenna Designed for Minimally Invasive Breast Tumor Ablation: Theoretical and Experimental Comparison of Temperature, Size of Lesion, and SWR, Preliminary Data

Cited by 11 publications

References 19 publications

Computational FEM Model and Phantom Validation of Microwave Ablation for Segmental Microcalcifications in Breasts Using a Coaxial Double-Slot Antenna

Computational FEM Model and Phantom Validation of Microwave Ablation for Segmental Microcalcifications in Breasts Using a Coaxial Double-Slot Antenna

Utilizing a Floating Sleeve Antenna for Interstitial Microwave Hyperthermia Treatment of Superficial and Deep-seated Breast Tumors

In-Silico Comparison of Thermal Microwave Ablation Therapy for Segmental Microcalcifications in Homogenous and Heterogenous Breast Tissue Models

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