Computational fluid dynamic simulations of a cavopulmonary assist device for failing Fontan circulation

Lin, Wu-Wei; Doyle, Matthew G.; Roche, S. Lucy; Honjo, Osami; Forbes, Thomas L.; Amón, Cristina H.

doi:10.1016/j.jtcvs.2019.03.008

Cited by 22 publications

(10 citation statements)

References 25 publications

(29 reference statements)

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“…Investigative collaboration with bioengineers and mathematicians has opened a new horizon in the research for mechanical circulatory support even in Fontan circulation, resulting in a large number of publications on the topic (177,238,(246)(247)(248)(249)(250)(251).…”

Section: Mathematical and Computational Fluid Dynamic Studiesmentioning

confidence: 99%

Narrative review of single ventricle: where are we after 40 years?

Corno¹,

Findley²,

Salazar³

2023

Transl Pediatr

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Background and Objective: Key medical and surgical advances have been made in the longitudinal management of patients with "functionally" single ventricle physiology, with the principles of Fontan circulation applied to other complex congenital heart defects. The purpose of this article is to review all of the innovations, starting from fetal life, that led to a change of strategy for single ventricle.Methods: Our literature review included all full articles published in English language on the Cochrane, MedLine, and Embase with references to "single ventricle" and "univentricular hearts", including the initial history of the treatments for this congenital heart defects as well as the innovations reported within the last decades.

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Section: Mathematical and Computational Fluid Dynamic Studiesmentioning

confidence: 99%

Narrative review of single ventricle: where are we after 40 years?

Corno¹,

Findley²,

Salazar³

2023

Transl Pediatr

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“…77 Our group is currently investigating a novel multilumen cannula to support the failing Fontan circulation by a computational fluid dynamic simulation model. 78 Improvements in palliation of single ventricle physiology have given rise to an increase in the number of single ventricle patients susceptible to HF later in life, which necessitates the use of some form of MCS. Supporting the failing myocardium in single ventricle patients is a complex challenging problem.…”

Section: Mcs In Achd Patients With Biventricular Physiologymentioning

confidence: 99%

Mechanical Circulatory Support for Patients With Adult Congenital Heart Disease

Haranal

Luo

Honjo

2020

Circ J

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Advances in surgical and medical care of children born with heart defects have led to the emergence of a unique subgroup of young adults known as adults with congenital heart disease (ACHD). Heart failure (HF) is the leading cause of mortality and morbidity in this subset. Management of HF is challenging in these patients owing to inherent structural variations with their associated physiological consequences. Heart transplantation is of limited utility in this group either because of donor shortage or associated comorbidities that make these patients ineligible for transplantation. Mechanical circulatory support (MCS) devices have evolved as an alternative treatment modality in supporting the failing myocardium of this population, but are often used less frequently than in those with a structurally normal heart because of the unique anatomical and physiological variations. These variations create a need to gather adequate knowledge on how best to support the hearts of ACHD patients in order to reduce mortality and morbidity. This review presents clinical experience with MCS in ACHD patients.

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“…Part of the solution may come from less invasive VADs for the pulmonary side of the circulation instituted sooner in the patient's course which remain at the developmental stage. [62][63][64]…”

Section: Vad In Fontan Patientsmentioning

confidence: 99%

Heart Failure in Adult Congenital Heart Disease: From Advanced Therapies to End-of-Life Care

Crossland

Bruaene

Silversides

et al. 2019

Canadian Journal of Cardiology

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There is mounting recognition that some of the most urgent problems of adult congenital heart disease (ACHD) are the prevention, diagnosis, and management of heart failure (HF). Recent expert consensus and position statements not only emphasize a specific and pressing need to tackle HF in ACHD (ACHD-HF) but also highlight the difficulty of doing so given a current sparsity of data. Some of the challenges will be addressed by this review. The authors are from 3 different centres; each centre has an established subspeciality ACHD-HF clinic and is able to provide heart transplant, multiorgan transplant, and mechanical support for patients with ACHD. Appropriate care of this complex population requires multidisciplinary ACHD-HF teams evaluate all possible treatment options. The risks and benefits of nontransplant ACHD surgery, percutaneous structural and electrophysiological intervention, and ongoing conservative management must be considered alongside those of transplant strategies. In our approach, advanced

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Computational fluid dynamic simulations of a cavopulmonary assist device for failing Fontan circulation

Cited by 22 publications

References 25 publications

Narrative review of single ventricle: where are we after 40 years?

Narrative review of single ventricle: where are we after 40 years?

Mechanical Circulatory Support for Patients With Adult Congenital Heart Disease

Heart Failure in Adult Congenital Heart Disease: From Advanced Therapies to End-of-Life Care

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