Computational Fluid Dynamics Analysis of a Maglev Centrifugal Left Ventricular Assist Device

Burgreen, Greg W.; Loree, H.; Bourque, Kevin; Dague, Charles; Poirier, Victor L.; Farrar, David J.; Hampton, Edward; Wu, Zhongjun J.; Gempp, Thomas; Schöb, Reto

doi:10.1111/j.1525-1594.2004.07384.x

Cited by 27 publications

(26 citation statements)

References 2 publications

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“…Computational fluid dynamic analyses are being increasingly adopted for analyzing the hemodynamic conditions within blood-wetted medical devices such as prosthetic heart valves, 5,14,18,19,41 blood pumps, [8][9][10] and vascular stents. 28,29 However, the interpretation of these simulation results in terms of thrombogenicity is not trivial.…”

Section: Discussionmentioning

confidence: 99%

Micro-Flow Visualization of Red Blood Cell-Enhanced Platelet Concentration at Sudden Expansion

et al. 2008

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Microscopic steps and crevices are inevitable features within prosthetic blood-contacting devices. This study aimed to elucidate the thrombogenicity of the associated microscopic flow features by studying the transport of fluorescent platelet-sized particles in a suspension of red blood cells (RBCs) flowing through a 100 microm:200 microm sudden expansion. Micro-flow visualization revealed a strong influence of hematocrit upon the path of RBCs and spatial concentration of particles. At all flow rates studied (Re = 8.3-41.7) and hematocrit 20% and lower, RBC streamlines were found to detach from the microchannel wall creating an RBC-depleted zone inside the step that was much larger than the cells themselves. However, the observed distribution of particles was relatively homogeneous. By contrast, the RBC streamlines of samples with hematocrit equal to or greater than 30% more closely followed the contour of the microchannel, yet exhibited enhanced concentration of particles within the corner. The corresponding size of the cell depletion layer was comparable with the size of the cells. This study implies that local platelet concentration in blood within the physiological range of hematocrit can be elevated within the flow separation region of a sudden expansion and implicates the role of RBCs in causing this effect.

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Section: Discussionmentioning

confidence: 99%

Micro-Flow Visualization of Red Blood Cell-Enhanced Platelet Concentration at Sudden Expansion

et al. 2008

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“…The implementations of these CFD packages are either based on the finite volume23 method or finite element method. Fluent 36, 37, 38, 39, 40, 41 and CFX 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 11, 57, 58, 59, both available from ANSYS, Inc. (Canonsburg, PA) and STAR-CD from CD-Adapco 60, 61 (Melville, New York) are the CFD software packages used most often for analysis and modelling of blood flow in VADs. In addition, AcuSolve from ACUSIM Software 62 (Mountain View, CA) and Adina from Adina R&D (Watertown, MA) are also used.…”

Section: Computational Techniquesmentioning

confidence: 99%

“…Most CFD studies of centrifugal pumps used multiple reference frames, however pumps which have been modelled using sliding meshes include Kyoto-NTN 38, HeartQuest CF4 48, HeartMate III 36 and EVAHEART 98. One study compared the use of sliding meshes with MRFs in the HeartQuest CF4 47.…”

Section: Solution Of Flow In a Moving Domainmentioning

confidence: 99%

The use of computational fluid dynamics in the development of ventricular assist devices

Fraser

Taşkın

Griffith

et al. 2011

Medical Engineering & Physics

234

236

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Progress in the field of prosthetic cardiovascular devices has significantly contributed to the rapid advancements in cardiac therapy during the last four decades. The concept of mechanical circulatory assistance was established with the first successful clinical use of heart-lung machines for cardiopulmonary bypass. Since then a variety of devices have been developed to replace or assist diseased components of the cardiovascular system. Ventricular assist devices (VADs) are basically mechanical pumps designed to augment or replace the function of one or more chambers of the failing heart.Computational Fluid Dynamics (CFD) is an attractive tool in the development process of VADs, allowing numerous different designs to be characterized for their functional performance virtually, for a wide range of operating conditions, without the physical device being fabricated. However, VADs operate in a flow regime which is traditionally difficult to simulate; the transitional region at the boundary of laminar and turbulent flow. Hence different methods have been used and the best approach is debatable. In addition to these fundamental fluid dynamic issues, blood consists of biological cells. Device-induced biological complications are a serious consequence of VAD use. The complications include blood damage (haemolysis, blood cell activation), thrombosis and emboli. Patients are required to take anticoagulation medication constantly which may cause bleeding. Despite many efforts blood damage models have still not been implemented satisfactorily into numerical analysis of VADs, which severely undermines the full potential of CFD. This paper reviews the current state of the art CFD for analysis of blood pumps, including a practical critical review of the studies to date, which should help device designers choose the most appropriate methods; a summary of blood damage models and the difficulties in implementing them into CFD; and current gaps in knowledge and areas for future work.

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“…It is sometimes formed in a narrow gap and by hemolysis. At present, CFD of thrombus formation is only analyzed by calculating the velocity distribution in the gap (Gobel et al 2001;Tsukamoto et al 2001;Burgreen et al 2004) and shear stress Nishida et al 2006a). Figure 13.15 shows the example of geometric optimization of the blood pump using CFD analysis and antithrombogenicity.…”

Section: Cfd Of Thrombus Formationmentioning

confidence: 99%

Vascular Engineering of Circulatory Assist Devices

Nishida

2016

Vascular Engineering

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Heart failure is a condition in which the heart cannot pump sufficiently because its contractile force has deteriorated. Patients with heart failure can sometimes undergo heart transplantation, but in number these patients comprise less than 10 % of patients actually requiring heart transplantation. Thus, mechanical circulatory assistance plays an important role in substituting for heart transplantation wherein the pump function of the heart is assisted by an artificial blood pump called a ventricular assist device. On the other hand, cardiopulmonary bypass is a form of extracorporeal circulation that temporarily takes over the function of the heart and lungs to maintain the circulation of blood and the oxygen content of the body during surgery for heart failure and aneurysms of the thoracic aorta. This chapter describes the vascular engineering of circulatory assist devices. Particular emphasis is placed on recent progress in ventricular assist devices and cardiopulmonary bypass pumps. These important medical devices assist with human circulation at either the chronic or the acute phase. Because these devices are derived from an industrial pump, a great many studies have been conducted not only from the medical perspective but also from industrial and engineering perspectives. In this chapter, current ventricular assist devices and cardiopulmonary bypass pumps, their specifications, their classifications, and methods for their design and evaluating are presented, including flow analysis inside the pump to optimize the geometry.

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Computational Fluid Dynamics Analysis of a Maglev Centrifugal Left Ventricular Assist Device

Cited by 27 publications

References 2 publications

Micro-Flow Visualization of Red Blood Cell-Enhanced Platelet Concentration at Sudden Expansion

Micro-Flow Visualization of Red Blood Cell-Enhanced Platelet Concentration at Sudden Expansion

The use of computational fluid dynamics in the development of ventricular assist devices

Vascular Engineering of Circulatory Assist Devices

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