2023
DOI: 10.3390/ijms24097886
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Computational Fluid Dynamics (CFD) Model for Analysing the Role of Shear Stress in Angiogenesis in Rheumatoid Arthritis

Abstract: Rheumatoid arthritis (RA) is an autoimmune disease characterised by an attack on healthy cells in the joints. Blood flow and wall shear stress are crucial in angiogenesis, contributing to RA’s pathogenesis. Vascular endothelial growth factor (VEGF) regulates angiogenesis, and shear stress is a surrogate for VEGF in this study. Our objective was to determine how shear stress correlates with the location of new blood vessels and RA progression. To this end, two models were developed using computational fluid dyn… Show more

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“…Shear stress can generally be recognized as a crucial trigger in vascular remodeling processes [ 16 ]. In this Special Issue, Motlana et al [ 17 ] describe how a computational fluid dynamics model can be used for analyzing the role of shear stress in angiogenesis in rheumatoid arthritis, as it represents an important factor [ 18 ]; they show that the magnitude of wall shear stress relates to the degree and extent of new blood vessel development.…”
mentioning
confidence: 99%
“…Shear stress can generally be recognized as a crucial trigger in vascular remodeling processes [ 16 ]. In this Special Issue, Motlana et al [ 17 ] describe how a computational fluid dynamics model can be used for analyzing the role of shear stress in angiogenesis in rheumatoid arthritis, as it represents an important factor [ 18 ]; they show that the magnitude of wall shear stress relates to the degree and extent of new blood vessel development.…”
mentioning
confidence: 99%