Computational fluid dynamics simulation of two-phase flow patterns in a serpentine microfluidic device

Amini, Younes; Ghazanfari, Valiyollah; Heydari, Mehran; Shadman, Mohammad Mahdi; Khamseh, Ali Gh.; Khani, Mohammad Hassan; Hassanvand, Amin

doi:10.1038/s41598-023-36672-6

Cited by 36 publications

(6 citation statements)

References 73 publications

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“…Biagini and co-workers developed a millifluidic device to generate fully controlled shear stress profiles and quantitatively probe their influence on tissue or bacterial models, overcoming the limitations of previously reported similar devices [28]. Amini and his group studied the flow behavior of a liquid-liquid (chloroform and water) extraction process in a serpentine microchannel [29]. The simulation was performed using a 3D model and the results were found to be consistent with experimental data.…”

Section: Discussionmentioning

confidence: 88%

Fluid Dynamics Optimization of Microfluidic Diffusion Systems for Assessment of Transdermal Drug Delivery: An Experimental and Simulation Study

Kocsis,

Dhinakaran,

Pandey

et al. 2024

Sci. Pharm.

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Organ-on-a-chip technologies show exponential growth driven by the need to reduce the number of experimental animals and develop physiologically relevant human models for testing drugs. In vitro, microfluidic devices should be carefully designed and fabricated to provide reliable tools for modeling physiological or pathological conditions and assessing, for example, drug delivery through biological barriers. The aim of the current study was to optimize the utilization of three existing skin-on-a-chip microfluidic diffusion chambers with various designs. For this, different perfusion flow rates were compared using cellulose acetate membrane, polyester membrane, excised rat skin, and acellular alginate scaffold in the chips. These diffusion platforms were integrated into a single-channel microfluidic diffusion chamber, a multi-channel chamber, and the LiveBox2 system. The experimental results revealed that the 40 µL/min flow rate resulted in the highest diffusion of the hydrophilic model formulation (2% caffeine cream) in each system. The single-channel setup was used for further analysis by computational fluid dynamics simulation. The visualization of shear stress and fluid velocity within the microchannel and the presentation of caffeine progression with the perfusion fluid were consistent with the measured data. These findings contribute to the development and effective application of microfluidic systems for penetration testing.

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Section: Discussionmentioning

confidence: 88%

Fluid Dynamics Optimization of Microfluidic Diffusion Systems for Assessment of Transdermal Drug Delivery: An Experimental and Simulation Study

Kocsis,

Dhinakaran,

Pandey

et al. 2024

Sci. Pharm.

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“…where P, τ, g, F σ , and ⊗ denote the pressure, stress tensor, gravitational force, surface tension, and outer product [30,47]. These equations, when solved numerically, enable the detailed modeling of wave dynamics and interactions within a wave flume.…”

Section: Simulation Settingsmentioning

confidence: 99%

CFD Analysis of Microplastic Transport over the Slopes

Quyen,

Park,

Lee

et al. 2024

JMSE

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Microplastics, ubiquitous in our environment, are significantly impacted by the hydrodynamic conditions around them. This study utilizes CFD to explore how various breaker types influence the dispersion and accumulation of microplastics in nearshore areas. A special focus is given to the impact of wave dynamics and particle size, particularly on buoyant microplastics in spilling breakers. It was discovered that spilling breakers, common on gently sloping seabeds, encourage broad dispersion of microplastics, notably for smaller-sized particles. Plunging breakers exhibit a similar pattern but with less dispersion and an initial forward movement of neutral and heavy particles. Surging breakers feature minimal dispersion and a distinct oscillatory motion. It has been observed that medium-sized particles with a 1 mm diameter in this work exhibit the most substantial forward movement, likely due to an optimal balance between inertia and viscosity, enabling an effective response to wave momentum. Larger particles, influenced mainly by inertia, tend to show less dispersion and advection. Meanwhile, smaller particles, more affected by viscosity, demonstrate greater dispersion, interacting extensively with wave-induced turbulence. This study reveals the significance of inertia in the behavior of microplastics over slopes, emphasizing the importance of considering inertial effects for precise modeling of microplastic movement in nearshore areas.

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“…The volume of fluid (VOF) model can simulate two or more immiscible fluids by solving individual momentum equations and processing the volume fraction of each phase passing through the entire region [19,22].…”

Section: Vof Modelmentioning

confidence: 99%

Simulation of Fluid Flow in the Top–Bottom Combined Blowing Converter

Liu,

Cheng,

Peng

2024

Metals

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The flow in the top–bottom combined blowing converter has an important impact on processes such as slagging, dephosphorization, decarburization, the heating of molten steel, and the homogenization of steel composition and temperature. A 1/6 reduced scale model based on a 210 t converter was used for the mathematical simulation. The validity of the model was verified by comparing the variation in cavity sizes caused by changes in the lance height and flow rate of the physical model with the numerical results. It was found that, in the bottom blowing converter, the area with higher velocity was distributed in the inverted conical plume. In top blowing, the area with higher velocity was distributed on the surface of a molten bath. The area of higher molten bath velocity in the combined blowing converter further increased. Compared with the top blowing converter, the increased percentage of the area-averaged velocity in the combined blowing converter first increased and then decreased as the distance from the bottom increased. When the top blowing flow rate changed, the combined blowing made the velocity change at the top of a molten bath smaller. The decrease in lance height significantly reduced the ratio of “inactive zone”, while the effect of the change in the flow rate was slight.

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Computational fluid dynamics simulation of two-phase flow patterns in a serpentine microfluidic device

Cited by 36 publications

References 73 publications

Fluid Dynamics Optimization of Microfluidic Diffusion Systems for Assessment of Transdermal Drug Delivery: An Experimental and Simulation Study

Fluid Dynamics Optimization of Microfluidic Diffusion Systems for Assessment of Transdermal Drug Delivery: An Experimental and Simulation Study

CFD Analysis of Microplastic Transport over the Slopes

Simulation of Fluid Flow in the Top–Bottom Combined Blowing Converter

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