Computational frame of ligament in situ strain in a full knee model

Adouni, Malek; Faisal, Tanvir R.; Dhaher, Yasin Y.

doi:10.1016/j.compbiomed.2020.104012

Cited by 13 publications

(18 citation statements)

References 71 publications

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“…The above results supported first the validity of the proposed model to predict the physiological stress of the ACL and the reported importance of the crosslinks content on the elasticity of the ligaments [22]. An alteration of this content may clearly affect the principal role of the ACL in preventing laxity or stiffness of the kinematics of the knee joint during human activities [67].…”

Section: Discussionsupporting

confidence: 77%

The Effect of Enzymatic Crosslink Degradation on the Mechanics of the Anterior Cruciate Ligament: A Hybrid Multi-Domain Model

et al. 2021

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The anterior cruciate ligament’s (ACL) mechanics is an important factor governing the ligament’s integrity and, hence, the knee joint’s response. Despite many investigations in this area, the cause and effect of injuries remain unclear or unknown. This may be due to the complexity of the direct link between macro- and micro-scale damage mechanisms. In the first part of this investigation, a three-dimensional coarse-grained model of collagen fibril (type I) was developed using a bottom-up approach to investigate deformation mechanisms under tensile testing. The output of this molecular level was used later to calibrate the parameters of a hierarchical multi-scale fibril-reinforced hyper-elastoplastic model of the ACL. Our model enabled us to determine the mechanical behavior of the ACL as a function of the basic response of the collagen molecules. Modeled elastic response and damage distribution were in good agreement with the reported measurements and computational investigations. Our results suggest that degradation of crosslink content dictates the loss of the stiffness of the fibrils and, hence, damage to the ACL. Therefore, the proposed computational frame is a promising tool that will allow new insights into the biomechanics of the ACL.

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Section: Discussionsupporting

confidence: 77%

The Effect of Enzymatic Crosslink Degradation on the Mechanics of the Anterior Cruciate Ligament: A Hybrid Multi-Domain Model

et al. 2021

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“…This role is well documented as a principal constraint for anterior translation and as a secondary restraint for frontal and transversal rotations. Thus, the decrease in the tissue toughness by means of molecular degradation will increase the laxity of the joint and the rotational instability in the coupled planes (frontal-transversal) (Adouni et al, 2020;. The spatial distribution of the plastic changes (damage) of the ACL was presented in terms of fibril plastic elongation (λ p ).…”

Section: Discussionmentioning

confidence: 99%

Biomechanics of the anterior cruciate ligament under simulated molecular degradation

Adouni¹,

Gouissem²,

Khatib³

et al. 2022

eCM

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Injuries to the knee anterior cruciate ligament (ACL) are common, with a known but poorly understood association with intrinsic and extrinsic risk factors. Some of these factors are enzymatically or mechanically mediated, creating acute focal injuries that may cause significant ligament damage. Understanding the relationship between the basic molecular structure and external loading of the ACL requires a hierarchical connection between the two levels. In the present study, a multi-domain frame was developed connecting the molecular dynamics of the collagen networks to the continuum mechanics of the ACL. The model was used to elucidate the effect of the two possible collagen degradation mechanisms on the aggregate ACL behaviour. Results indicated that collagen content and ACL stiffness were reduced significantly, regardless of the degradation mechanism. Furthermore, the volumetric degradation at the molecular level had a devastating effect on the mechanical behaviour of the ACL when it was compared with the superficial degradation. ACL damage initiation and propagation were clearly influenced by collagen degradation. To summarise, the new insights provided by the predicted results revealed the significance of the collagen network structural integrity to the aggregate mechanical response of the ACL and, hence, underlined the biomechanical factors that may help develop an engineering-based approach towards improving the therapeutic intervention for ACL pathologies.

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“…The pre-strains’ behavior was incorporated into the ligaments by decomposing the deformation gradient ( F = F 0 F r ) into a stress-free state ( F 0 ) and reference state ( Fr ). The pre-strains were defined here as the initial stretch (

) field with F 0 =

[ 39 ]. The current study considered the sets of material parameters from our recent publication [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

“…The pre-strains were defined here as the initial stretch (

) field with F 0 =

[ 39 ]. The current study considered the sets of material parameters from our recent publication [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

“…Next, the ground reaction force and leg/foot weights were applied to regenerate the joint reaction moments [ 43 ]. After that, unknown forces in muscles were iteratively approximated and applied as additional external loads to the model by updating the optimization algorithm with residual reaction moments and edited muscle lever arms owing to the passive resistance ( Figure 1 ) [ 39 , 44 ]. The convergence is obtained when the needed moments fall below 1 N.m. Abaqus statics analysis and Matlab genetic algorithm were used.…”

Section: Methodsmentioning

confidence: 99%

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Biomechanical Characteristics of the Knee Joint during Gait in Obese versus Normal Subjects

Khatib

Gouissem

Mbarki

et al. 2022

IJERPH

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Knee osteoarthritis (OA) is a growing source of pain and disability. Obesity is the most important avoidable risk factor underlying knee OA. The processes by which obesity impacts osteoarthritis are of tremendous interest to osteoarthritis researchers and physicians, where the joint mechanical load is one of the pathways generally thought to cause or intensify the disease process. In the current work, we developed a hybrid framework that simultaneously incorporates a detailed finite element model of the knee joint within a musculoskeletal model to compute lower extremity muscle forces and knee joint stresses in normal-weight (N) and obese (OB) subjects during the stance phase gait. This model accounts for the synergy between the active musculature and passive structures. In comparing OB subjects and normal ones, forces significantly increased in all muscle groups at most instances of stance. Mainly, much higher activation was computed with lateral hamstrings and medial gastrocnemius. Cartilage contact average pressure was mostly supported by the medial plateau and increased by 22%, with a larger portion of the load transmitted via menisci. This medial compartment experienced larger relative movement and cartilage stresses in the normal subjects and continued to do so with a higher level in the obese subjects. Finally, the developed bioengineering frame and the examined parameters during this investigation might be useful clinically in evaluating the initiation and propagation of knee OA.

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Computational frame of ligament in situ strain in a full knee model

Cited by 13 publications

References 71 publications

The Effect of Enzymatic Crosslink Degradation on the Mechanics of the Anterior Cruciate Ligament: A Hybrid Multi-Domain Model

The Effect of Enzymatic Crosslink Degradation on the Mechanics of the Anterior Cruciate Ligament: A Hybrid Multi-Domain Model

Biomechanics of the anterior cruciate ligament under simulated molecular degradation

Biomechanical Characteristics of the Knee Joint during Gait in Obese versus Normal Subjects

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