“…In general, practical improvements depended on experimental data from chemical process modeling and analysis, and this method was considered as a safe and efficient way to achieve the goal of stable production, high profits, and low cost. Because of the complexity and uncertainty of modern industrial systems, computational intelligence has become a new technique for system modeling and optimization . Recently, inspired by various immune metaphors, immune algorithm, one of the new computational intelligence methods, has drawn significant attention from the researchers. − The significant work includes CLONALG, RAIN, and aiNet, etc.…”