Computational Intelligence-Based Gene Expression Analysis in Colorectal Cancer: A Review

Srivastava, Ankit; Rai, Suresh; Singh, Manish Pratap; Srivastava, Sameer

doi:10.1007/978-981-16-9221-5_22

Cited by 8 publications

(3 citation statements)

References 71 publications

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“…To determine the potential target for the selected lead compound, the ChemMapper and PharmMapper server (http://www.lilab-ecust.cn/chemmapper/ and https://www.lilabecust.cn/pharmmapper/), respectively utilized (Trosset, 2019;Srivastava et al, 2022). The lead compound was submitted in sdf format, and the target set was limited to human targets while all other parameters were kept as default.…”

Section: Identification Of Targetmentioning

confidence: 99%

Exploring the Potential of Furofuran Lignans Isolated from Beilschmiedia pulverulenta for Drug Development: A Computational Approach

SALİHU,

SALLEH

2023

Yüzüncü Yıl Üniversitesi Tarım Bilimleri Dergisi

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Natural products have played a significant role in drug discovery and continue to be an important source of lead for new drugs. In recent years, computer-based drug discovery methods have emerged as an effective approach for identifying small molecule leads with desirable pharmacokinetic and toxicity profiles. This study investigated the pharmacological and bioactivity of five furofuran lignans, namely, epiexcelsin, sesamin, sesartemin, syringaresinol, and yangambin, isolated from the plant Beilschmiedia pulverulenta. In silico studies were conducted to predict the pharmacological activities, toxicity, and drug likeliness properties of the lead compounds. The results showed that all compounds had promising pharmacokinetic activities, with epiexcelsin exhibiting strong binding affinity (-8.13 kcal mol-1) and inhibitory activity (1.1 µM) against estrogen receptor-α, and predicted to be bioavailable and effective lead. The findings of this study provide important insights into the potential therapeutic uses of natural medicinal plants and emphasize the potential of combining traditional medicinal knowledge with modern scientific approaches in drug discovery. Overall, the furofuran lignans isolated from Beilschmiedia pulverulenta represent a promising source of natural compounds for the development of effective drugs.

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Section: Identification Of Targetmentioning

confidence: 99%

Exploring the Potential of Furofuran Lignans Isolated from Beilschmiedia pulverulenta for Drug Development: A Computational Approach

SALİHU,

SALLEH

2023

Yüzüncü Yıl Üniversitesi Tarım Bilimleri Dergisi

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“…Colorectal cancer (CRC) is one of the most common cancers, mainly due to alterations in genetic and epigenetic factors that lead to tumor progression and development [116,117]. Several NPs have been identified that play a significant role in stimulating various important signaling pathways, thus leading to CRC development [118].…”

Section: Emerging Neuropeptides Inhibitors In Colorectal Cancermentioning

confidence: 99%

An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives

et al. 2022

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Neuropeptides are mainly secreted from the human central and peripheral nervous systems. Neuropeptides bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) and perform various physiological functions. Conventional cancer treatments in clinical practice still present many drawbacks due to the lack of selectivity toward the target cell, drug-resistance, and side-effects, thus pushing for the development of new therapeutic agents and therapies. Recent research suggests that neuropeptides influence cancer cell proliferation, invasion, metastasis, and angiogenesis and, therefore, they could be exploited as a target for novel anticancer therapies. Very recently, targeted approaches that inhibit neuropeptides and their associated receptors are being developed in cancer treatment. This review focuses on various neuropeptides and their potential utility as drug targets by different inhibitors as a recently identified approach to cancer prevention, with particular emphasis on colorectal cancer.

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“… 4 In addition, alterations such as mutations, chromosomal structural variants, microsatellite instability, gene fusions, altered gene expression, and epigenetic inactivation in cancer hallmark genes have been implicated in CRC development. 5 In the case of CRC, earlier studies have identified alterations in genes such as KRAS, NRAS, c-Myc, APC, TP53, CTNNB1, PIK3CA, and mismatch repair (MMR) genes with significant frequency in the number of CRC cases. 6 , 7 In recent years, researchers have also identified several new genes that serve as a potential therapeutic target (e.g., LGR4-6, RNF43, ZNRF3, RSPO2, ANO5, SLITRK1, NRXN1, and ANK2) and are linked to the CRC development.…”

Section: Introductionmentioning

confidence: 99%

RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunities

Srivastava¹,

Rikhari²,

Srivastava³

2024

Genes & Diseases

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Computational Intelligence-Based Gene Expression Analysis in Colorectal Cancer: A Review

Cited by 8 publications

References 71 publications

Exploring the Potential of Furofuran Lignans Isolated from Beilschmiedia pulverulenta for Drug Development: A Computational Approach

Exploring the Potential of Furofuran Lignans Isolated from Beilschmiedia pulverulenta for Drug Development: A Computational Approach

An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives

RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunities

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