Computational Investigation to Design Ofloxacin-Loaded Hybridized Nanocellulose/Lipid Nanogels for Accelerated Skin Repair

AbouSamra, Mona M.; Hoffy, Nada M. El; El-Wakil, Nahla A.; Awad, Ghada E. A.; Kamel, Rabab

doi:10.3390/gels8090593

Cited by 4 publications

(3 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Biomedical Applications Of Nanocellulose Hydrogelsmentioning

confidence: 99%

“…An advanced wound management strategy is the encapsulation of antimicrobial agents in hydrogels for bacteria-associated wounds as studies show, for example, that subsequent infections account for more a than 75% morbidity rate in burn patients [145]. For instance, antimicrobials such as antibiotics (levofloxacin [146], bacitracin, amoxicillin [147], vancomycin, ciprofloxacin [148], ofloxacin [149], clindamycin hydrochloride [150]), silver nanoparticles [151,152], metal cations [153], and natural compound (thymol [154], alpha-tocopherol [155], propolis [156], curcumin [157], oregano essential oil [158], vitamin C,E [159], diosgenin [160] and resveratrol [161])-loaded NCs-based hydrogels have been reported (Table 6). Hemostatic feature and accelerated cutaneous wound healing in rat punch biopsy model [165] Abbreviations: CMC-carboxymethylcellulose; DOP-dopamine; GMA-glycidylmethacrylate; EGDMA-ethylene glycol dimethacrylate; PVA-poly(vinyl alcohol); OCMC-DAdopamine-grafted oxidized carboxymethyl cellulose; LMP-low methoxy pectin; SA-sodium alginate; HaCaT cell-human epidermal keratinocytes; GEL-gelatin; ALG-alginate; P-pluronic ® F-127; PVP-polyvinyl pyrollidone; PUL-pullulan; B-borax; CHI-chitosan; S. aureus-Staphylococcus aureus; E. Coli-Escherichia coli; P. aeruginosa-Pseudomonas aeruginosa; C. auris-Candida auris; S. epidermidis-Staphylococcus epidermidis.…”

Section: Wound Dressingsmentioning

confidence: 99%

See 1 more Smart Citation

Insight into the Latest Medical Applications of Nanocellulose

Ghilan¹,

Nicu²,

Ciolacu³

et al. 2023

Materials

View full text Add to dashboard Cite

Nanocelluloses (NCs) are appealing nanomaterials that have experienced rapid development in recent years, with great potential in the biomedical field. This trend aligns with the increasing demand for sustainable materials, which will contribute both to an improvement in wellbeing and an extension of human life, and with the demand to keep up with advances in medical technology. In recent years, due to the diversity of their physical and biological properties and the possibility of tuning them according to the desired goal, these nanomaterials represent a point of maximum interest in the medical field. Applications such as tissue engineering, drug delivery, wound dressing, medical implants or those in cardiovascular health are some of the applications in which NCs have been successfully used. This review presents insight into the latest medical applications of NCs, in the forms of cellulose nanocrystals (CNCs), cellulose nanofibers (CNFs) and bacterial nanocellulose (BNC), with an emphasis on the domains that have recently experienced remarkable growth, namely wound dressing, tissue engineering and drug delivery. In order to highlight only the most recent achievements, the presented information is focused on studies from the last 3 years. Approaches to the preparation of NCs are discussed either by top-down (chemical or mechanical degradation) or by bottom-up (biosynthesis) techniques, along with their morphological characterization and unique properties, such as mechanical and biological properties. Finally, the main challenges, limitations and future research directions of NCs are identified in a sustained effort to identify their effective use in biomedical fields.

show abstract

Section: Biomedical Applications Of Nanocellulose Hydrogelsmentioning

confidence: 99%

Section: Wound Dressingsmentioning

confidence: 99%

Insight into the Latest Medical Applications of Nanocellulose

Ghilan¹,

Nicu²,

Ciolacu³

et al. 2023

Materials

View full text Add to dashboard Cite

show abstract

“…The multiple benign properties of cellulose have encouraged its exploitation in the pharmaceutical field [9][10][11][12]. Recently, our team used nanocellulose isolated from agrowastes (e.g., sugarcane bagasse) as a pharmaceutical ingredient for formulations designed for tissue regeneration [13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Cellulosic Textiles—An Appealing Trend for Different Pharmaceutical Applications

Nocca,

Arcovito,

Elkasabgy

et al. 2023

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Cellulose, the most abundant biopolymer in nature, is derived from various sources. The production of pharmaceutical textiles based on cellulose represents a growing sector. In medicated textiles, textile and pharmaceutical sciences are integrated to develop new healthcare approaches aiming to improve patient compliance. Through the possibility of cellulose functionalization, pharmaceutical textiles can broaden the applications of cellulose in the biomedical field. This narrative review aims to illustrate both the methods of extraction and preparation of cellulose fibers, with a particular focus on nanocellulose, and diverse pharmaceutical applications like tissue restoration and antimicrobial, antiviral, and wound healing applications. Additionally, the merging between fabricated cellulosic textiles with drugs, metal nanoparticles, and plant-derived and synthetic materials are also illustrated. Moreover, new emerging technologies and the use of smart medicated textiles (3D and 4D cellulosic textiles) are not far from those within the review scope. In each section, the review outlines some of the limitations in the use of cellulose textiles, indicating scientific research that provides significant contributions to overcome them. This review also points out the faced challenges and possible solutions in a trial to present an overview on all issues related to the use of cellulose for the production of pharmaceutical textiles.

show abstract