“…Along with the objective variable, exploratory variables such as age, gender, and analysis period are also included, since the aim of this paper is proper management of the budget for medical care [33]. A review that highlights the applications of machine learning techniques in various medical practices such as predicting, diagnosing, and prognosis of diseases such as multiple sclerosis, autoimmune chronic kidney disease, autoimmune rheumatic disease, and inflammatory bowel disease and for the selection of treatments and stratification of patients; drug development; drug repurposing; target interpretation; and validation has been given in [34,35]. is paper also provides a detailed description of the challenges faced by the machine learning approaches such as the need for quality data in preparation of robust models, external model validation using the independent data set, difficulties faced during implementation of a model, and ethical concerns.…”