Computational modeling of an endovascular approach to deep brain stimulation

Teplitzky, Benjamin A.; Connolly, Allison T.; Bajwa, Jawad A.; Johnson, Matthew D.

doi:10.1088/1741-2560/11/2/026011

Cited by 33 publications

(39 citation statements)

References 92 publications

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“…Electrodes positioned temporarily within intracranial vessels enabled recording of both spontaneous and evoked EEG-like electrical activity (Driller et al, 1969), and this work was recently extended to multi-electrode recordings using a chronically implanted stent-like device (Oxley et al, 2016). Stimulation through the blood vessel wall is also possible, an example being endovascular stimulation of the vagus nerve (Nabutovsky et al, 2007), and a recent simulation analysis demonstrated comparable patterns of model nerve fiber activation between an intravascular electrode and traditional stereotactically-positioned DBS leads (Teplitzky et al, 2014). This is not to suggest that intravascular methods are without risk; however, such innovations may provide a less-invasive approach to both record and stimulate deep in the brain and thus, represent new way to deliver DBS.…”

Section: Development In Technology and Applicationmentioning

confidence: 99%

Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies

Deeb

Giordano

Rossi

et al. 2016

Front. Integr. Neurosci.

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This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome. Next, advances in the use of neuroimaging and electrochemical markers to enhance DBS specificity were addressed. Updates on ongoing use and developments of DBS for the treatment of Parkinson's disease, essential tremor, Alzheimer's disease, depression, post-traumatic stress disorder, obesity, addiction were presented, and progress toward innovation(s) in closed-loop applications were discussed. Each section of these proceedings provides updates and highlights of new information as presented at this year's international Think Tank, with a view toward current and near future advancement of the field.

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Section: Development In Technology and Applicationmentioning

confidence: 99%

Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies

Deeb

Giordano

Rossi

et al. 2016

Front. Integr. Neurosci.

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“…Teplitzky et al also demonstrated that with a unilateral electrode implant, endovascular DBS was superior to stereotactic DBS in the production of contralateral activation and comparable to stereotactic DBS in neuronal activation. 31 Further investigation into the stimulation parameters (such as the current levels) and the safety profile of intravascular stimulation is necessary.…”

Section: Deep Brain Stimulationmentioning

confidence: 99%

“…Endovascular EEG could be used in the preoperative evaluation of patients for epilepsy surgery, 5,16,19,22 or even in the determination of resection margins that could possibly be treated endovascularly. 2 In addition, computational modeling has demonstrated the feasibility of an endovascular approach to DBS, 31 and the ability to chronically record in the superior sagittal sinus superficial to the sensorimotor cortex 22 may lead to the achievement of a minimally invasive BMI.…”

Section: 1922mentioning

confidence: 99%

The evolution of endovascular electroencephalography: historical perspective and future applications

Sefcik¹,

Opie

John

et al. 2016

FOC

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Current standard practice requires an invasive approach to the recording of electroencephalography (EEG) for epilepsy surgery, deep brain stimulation (DBS), and brain-machine interfaces (BMIs). The development of endovascular techniques offers a minimally invasive route to recording EEG from deep brain structures. This historical perspective aims to describe the technical progress in endovascular EEG by reviewing the first endovascular recordings made using a wire electrode, which was followed by the development of nanowire and catheter recordings and, finally, the most recent progress in stent-electrode recordings. The technical progress in device technology over time and the development of the ability to record chronic intravenous EEG from electrode arrays is described. Future applications for the use of endovascular EEG in the preoperative and operative management of epilepsy surgery are then discussed, followed by the possibility of the technique's future application in minimally invasive operative approaches to DBS and BMI.

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“…Axon models consisted of 2 μm diameter fibers with compartments representing nodes of Ranvier, myelin attachment segments, paranode main segments, and internode segments connected through an axial resistance [16]. Axonal membrane compartments were each driven using the extracellular mechanism in NEURON (e_extracellular) [6], [8], [43]. We applied a waveform with a 90 μs cathode-leading phase, 400 μs interphase delay, 3 ms charge-balanced anodic phase, and 135 Hz pulse rate [44].…”

Section: Methodsmentioning

confidence: 99%

Particle swarm optimization for programming deep brain stimulation arrays

et al. 2017

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Objective Deep brain stimulation (DBS) therapy relies on both precise neurosurgical targeting and systematic optimization of stimulation settings to achieve beneficial clinical outcomes. One recent advance to improve targeting is the development of DBS arrays (DBSAs) with electrodes segmented both along and around the DBS lead. However, increasing the number of independent electrodes creates the logistical challenge of optimizing stimulation parameters efficiently. Approach Solving such complex problems with multiple solutions and objectives is well known to occur in biology, in which complex collective behaviors emerge out of swarms of individual organisms engaged in learning through social interactions. Here, we developed a particle swarm optimization (PSO) algorithm to program DBSAs using a swarm of individual particles representing electrode configurations and stimulation amplitudes. Using a finite element model of motor thalamic DBS, we demonstrate how the PSO algorithm can efficiently optimize a multi-objective function that maximizes predictions of axonal activation in regions of interest (ROI, cerebellar-receiving area of motor thalamus), minimizes predictions of axonal activation in regions of avoidance (ROA, somatosensory thalamus), and minimizes power consumption. Main Results The algorithm solved the multi-objective problem by producing a Pareto front. ROI and ROA activation predictions were consistent across swarms (<1% median discrepancy in axon activation). The algorithm was able to accommodate for (1) lead displacement (1 mm) with relatively small ROI (≤9.2%) and ROA (≤1%) activation changes, irrespective of shift direction; (2) reduction in maximum per-electrode current (by 50% and 80%) with ROI activation decreasing by 5.6% and 16%, respectively; and (3) disabling electrodes (n=3 and 12) with ROI activation reduction by 1.8% and 14%, respectively. Additionally, comparison between PSO predictions and multi-compartment axon model simulations showed discrepancies of <1% between approaches. Significance The PSO algorithm provides a computationally efficient way to program DBS systems especially those with higher electrode counts.

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Computational modeling of an endovascular approach to deep brain stimulation

Abstract: Together, these results suggest that endovascular DBS can serve as a complementary approach to stereotactic DBS in select cases.

Cited by 33 publications

References 92 publications

Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies

Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies

The evolution of endovascular electroencephalography: historical perspective and future applications

Particle swarm optimization for programming deep brain stimulation arrays

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