Computational Modeling of Purinergic Receptor Activation in Microglia

Abstract

rises. The SK conductance increases again to a peak of 7.2 nS as the action potential drops below 0 mV and [Ca 2þ ] sm decreases below 10 mM. This is the region of the action potential where the VCMs are most sensitive to early afterdepolarizations due to reactivation of L-type Ca 2þ channels and enhanced activity of the Na þ /Ca 2þ exchanger, suggesting SK channels have a potential anti-arrhythmic effect.