Computational Modeling of Thermal Ablation Zones in the Liver: A Systematic Review

van Erp, Gonnie C. M.; Hendriks, Pim; Broersen, Alexander; Verhagen, Coosje A. M.; Gholamiankhah, Faeze; Dijkstra, Jouke; Burgmans, Mark C.

doi:10.3390/cancers15235684

Cited by 3 publications

(1 citation statement)

References 69 publications

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“…Treatment planning [35] , [36] , [37] and computational models are important tools currently under development for many modalities to guide and tailor interstitial thermal ablation procedures and may provide for safer and more effective outcomes [38] , [39] , [40] . These planning and modeling tools can determine optimal designs and patterns of use, and through patient specific treatment planning optimize the device operating parameters and placement to selectively improve the tumor or target ablative temperature and thermal dose coverage.…”

Section: Introductionmentioning

confidence: 99%

Treatment Planning Strategies for Interstitial Ultrasound Ablation of Prostate Cancer

Gupta,

Heffter,

Zubair

et al. 2024

IEEE Open J. Eng. Med. Biol.

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To develop patient-specific 3D models using Finite-Difference Time-Domain (FDTD) simulations and pre-treatment planning tools for the selective thermal ablation of prostate cancer with interstitial ultrasound. This involves the integration with a FDA 510(k) cleared catheter-based ultrasound interstitial applicators and delivery system. Methods: A 3D generalized "prostate" model was developed to generate temperature and thermal dose profiles for different applicator operating parameters and anticipated perfusion ranges. A priori planning, based upon these pre-calculated lethal thermal dose and iso-temperature clouds, was devised for iterative device selection and positioning. Full 3D patient-specific anatomic modeling of actual placement of single or multiple applicators to conformally ablate target regions can be applied, with optional integrated pilot-point temperature-based feedback control and urethral/rectum cooling. These numerical models were verified against previously reported ex-vivo experimental results obtained in soft tissues. Results: For generic prostate tissue, 360 treatment schemes were simulated based on the number of transducers (1-4), applied power (8-20 W/cm 2 ), heating time (5, 7.5, 10 min), and blood perfusion (0, 2.5, 5 kg/m 3 /s) using forward treatment modelling. Selectable ablation zones ranged from 0.8-3.0 cm and 0.8-5.3 cm in radial and axial directions, respectively. 3D patientspecific thermal treatment modeling for 12 Cases of T2/T3 prostate disease demonstrate applicability of workflow and technique for focal, quadrant and hemi-gland ablation. A temperature threshold (e.g., Tthres = 52 °C) at the treatment margin, emulating placement of invasive temperature sensing, can be applied for pilot-point feedback control to improve conformality of thermal ablation. Also, binary power control (e.g., Treg = 45 °C) can be applied which will regulate the applied power level to maintain the surrounding temperature to a safe limit or maximum threshold until the set heating time. Conclusions: Prostate-specific simulations of interstitial ultrasound applicators were used to generate a library of thermal-dose distributions to visually optimize and set applicator positioning and directivity during a priori treatment planning pre-procedure. Anatomic 3D forward treatment planning in patient-specific models, along with optional temperature-based feedback control, demonstrated single and multi-applicator

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Section: Introductionmentioning

confidence: 99%

Treatment Planning Strategies for Interstitial Ultrasound Ablation of Prostate Cancer

Gupta,

Heffter,

Zubair

et al. 2024

IEEE Open J. Eng. Med. Biol.

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Use of Palliative Site‐Directed Ablation in Pediatric Oncology: A Retrospective Study From the Pediatric Surgical Oncology Research Collaborative

Talbot,

Schechter,

Mothi

et al. 2024

Pediatric Blood & Cancer

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BackgroundChildren with end‐stage solid tumors would benefit from established nonsurgical options for palliative site‐directed local control with the intent of improving quality of life (QOL) and extending survival. We investigated the practice and tolerability of palliative ablation strategies in patients with pediatric solid tumors.MethodsChildren and young adults with solid tumors ineligible for surgical site‐directed control were treated with palliative ablative strategies between 2010 and 2020 at five institutions participating in the Pediatric Surgical Oncology Research Collaborative. Demographic, histologic, and clinical data were retrospectively evaluated, and assessment of patient reasons for choosing ablative strategies was qualitatively assessed.ResultsA total of 69 patients underwent 89 ablative procedures for 132 lesions. More than 10 histologies were represented, the most common of which were Ewing sarcoma (n = 15 patients), osteosarcoma (n = 13 patients), and rhabdomyosarcoma (n = 9 patients). Ablation techniques included cryoablation (n = 9 procedures/16 lesions), radiofrequency ablation (RFA) (n = 4 procedures/5 lesions), microwave ablation (MWA) (n = 5 procedures/12 lesions), and stereotactic body radiotherapy (SBRT) (n = 68 procedures/99 lesions). Grade 3 or higher adverse events (AEs) included pain requiring IV medication in cryoablation (three out of 12 procedures), RFA (one out of four procedures), and MWA (two out of five procedures), bleeding in MWA (two out of five procedures), and skin burns requiring surgical intervention in SBRT (one out of 68 procedures). Patients were generally hospitalized after percutaneous ablation (19 out of 21 cryoablation, RFA, and MWA procedures) but the hospital stay was short (mean/SD 1 ± 4 days). Only four patients who were already hospitalized experienced hospitalization extension due to undergoing an ablative procedure. The primary reason for pursuing ablative measures could be broadly categorized into four groups: treatment of unresectable disease either due to surgical inaccessibility or metastasis (n = 31), symptom relief, either pain or mass effect (n = 25), specific patient QOL concerns unrelated to pain or life prolongation (n = 5), and physiologic instability for otherwise resectable disease (n = 4). All patients undergoing treatment for symptom relief received SBRT.ConclusionIn this cohort of patients undergoing palliative treatment of incurable or unresectable pediatric solid tumors, ablation strategies were well tolerated. Further research is needed to determine patient reported outcomes after ablation strategies are pursued and patient and family satisfaction with the choice for ablative strategies. An understanding of institutional availability and ability to employ these strategies would also be informative.

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Radiofrequency ablation of hepatocellular carcinoma guided by real-time physics-based ablation simulation: a prospective study

Hoffer,

Drinane,

Bhatnagar

et al. 2024

International Journal of Hyperthermia

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Computational Modeling of Thermal Ablation Zones in the Liver: A Systematic Review

Cited by 3 publications

References 69 publications

Treatment Planning Strategies for Interstitial Ultrasound Ablation of Prostate Cancer

Treatment Planning Strategies for Interstitial Ultrasound Ablation of Prostate Cancer

Use of Palliative Site‐Directed Ablation in Pediatric Oncology: A Retrospective Study From the Pediatric Surgical Oncology Research Collaborative

Radiofrequency ablation of hepatocellular carcinoma guided by real-time physics-based ablation simulation: a prospective study

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