Computational modelling and data analysis on the virulence of influenza viruses

Abstract

This thesis contains material from seven papers published in the following peer-reviewed journals and papers accepted at conferences in which I am listed as an author.Chapter 3 is published as:(a) Fransiskus Xaverius Ivan, Xinrui Zhou, Akhila Deshpande, Rui Yin, Jie Zheng, and Chee Keong Kwoh. Phylogenetic tree based method for uncovering co-mutational site-pairs in influenza viruses. In Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics, pages 21-26. ACM, 2017• FXI conceived the idea, directed the project. XZ and AD conducted the experiments, interpreted the results, and edited the manuscript. RY and JZ vetted through the manuscript. CK provided overall supervision to the research.(b) Haifen Chen, Xinrui Zhou, Jie Zheng, and Chee-Keong Kwoh. Rules of co-occurring mutations characterize the antigenic evolution of human influenza A/H3N2, A/H1N1 and B viruses.