Computational Modelling of Cholera Bacteriophage with Treatment

Abstract

This paper examines the computational modelling of cholera bacteriophage with treatment. A nonlinear mathematical model for cholera bacteriophage and treatment is formulated and analysed. The effective reproduction number of the nonlinear model system is calculated by next generation operator method. By using the next generation matrix approach, the disease-free equilibrium is found to be locally stable at threshold parameter less than unity and unstable at threshold parameter greater than unity. Globally, the disease free equilibrium point is not stable due to existence of forward bifurcation at threshold parameter equal to unity. Stability analysis and numerical simulations suggest that the combination of bacteriophage and treatment may contribute to lessening the severity of cholera epidemics by reducing the number of Vibrio cholerae in the environment. Hence with the presence of bacteriophage virus and treatment, cholera is self-limiting in nature.

A Caputo-Fabrizio fractional-order cholera model and its sensitivity analysis

“…Those who show symptoms may experience severe watery stool, vomiting, leg cramps, decreased blood pressure, kidney failure, and loss of body fluids or electrolytes (dehydration). If immediate treatment is not administered to halt these symptoms, they can potentially lead to death [1][2][3][4]. The incidence of cholera cases in Africa has been reported by the World Health Organization (WHO, 2021).…”

Stability Analysis and Numerical Simulation of Fractional Cholera Model

“…Furthermore, the next-generation matrix method was used to study cholera bacteriophage in the study by authors in [3]. Based on the analysis of the results, both the bacteriophage and the treatment decreased the number of cholera bacteria in the environment.…”