2012
DOI: 10.1016/j.seizure.2012.08.012
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Computational models of epilepsy

Abstract: We conclude with a discussion on the utility of computational models for the development of new epilepsy treatment protocols.

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Cited by 75 publications
(49 citation statements)
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References 107 publications
(105 reference statements)
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“…Recent efforts to design and implement closed-loop control of epileptic networks have focused on the site and stimulation parameters (Stefanescu et al, 2012; Fisher and Velasco, 2014). Ideally, electrical stimulation should be done solely on the epileptogenic network, and with accurate seizure foci localization techniques (Burns et al, 2012, 2014), it may be possible to implement micro electrode arrays at the epileptogenic brain site and measure spike trains as required by our controller scheme.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Recent efforts to design and implement closed-loop control of epileptic networks have focused on the site and stimulation parameters (Stefanescu et al, 2012; Fisher and Velasco, 2014). Ideally, electrical stimulation should be done solely on the epileptogenic network, and with accurate seizure foci localization techniques (Burns et al, 2012, 2014), it may be possible to implement micro electrode arrays at the epileptogenic brain site and measure spike trains as required by our controller scheme.…”
Section: Discussionmentioning
confidence: 99%
“…Computational modeling is a powerful tool for understanding the underlying mechanisms involved in seizure genesis and its dynamics, and has proven to be very useful in aiding with the design of more efficient seizure onset detectors and brain stimulation protocols (Stefanescu et al, 2012). We recently constructed a neuronal network model of the epileptic cortex that qualitatively captures the heterogeneity in neurons observed in patients during seizure events (Sritharan and Sarma, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Also, recently, both healthy and epilepticform brain activity have been simulated using cellular automata with long-range interactions [55]. Other mathematical and computational approaches have also been considered and the understanding and modelling of the mechanisms of epilepsy is an active research field nowadays [56].…”
Section: Discussionmentioning
confidence: 99%
“…Attempting to include all of these cells and cytokines in the model would introduce a number of unknown or not-well-defined parameters into the model. Simplifications are a critical component in the construction of effective and rigorous models and can help investigators to concentrate on a limited number of essential components in the simulated system [55]. This approach may sacrifice the power of simulating the subtle differences of different cytokines but yield a much clearer understanding of the critical components that lead to in-stent restenosis.…”
Section: Discussionmentioning
confidence: 99%