With the development of urbanization, the construction of the subway has been greatly developed. Meanwhile, the public concern of terrorist attacks on subway stations keeps driving the related research. In this paper, the representative subway station of Wuhan Metro Line 8, Mafangshan station, which is now under construction, is taken as a case, the dynamic finite element numerical simulation software ANSYS/LS-DYNA is employed to establish finite element model. The propagation law transmitting through the station structure and the dynamic response of the station under different TNT charges are analyzed. It is indicated that the propagation of shock wave is complicated due to the semi-closed environment of the station as well as the reflection and transmission of the stress wave in the structure. Specifically, in the station structure, the displacement of the platform plate was the largest, under the explosive action of different TNT charge, the displacement of platform plate is 13.6 mm (5 kg), 22. 8mm (10 kg), 35.2 mm (20 kg), 45.6 cm (30 kg), 68.8 cm (40 kg), respectively. The middle part of the pillar was the largest displacement on the pillar. Based on the dynamic stress response analysis of the station pillar, it shows that the maximum value of the stress value in the pillar is located at the junction of the pillar and the plate. Under the explosive action of 40 kg TNT charge, the maximum tensile stress of the junction of the pillar and the plate reached 45.1 MPa. Therefore, more attention should be paid to anti-explosion measures herein. Besides, through the analysis of the tensile stress value at the bottom of the pillar under different charge quantity, the TNT charge quantity for the crack at the bottom of the pillar is determined to be 6.77 kg by the formula fitting.