2022
DOI: 10.3389/fimmu.2022.807840
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Computational Recognition of a Regulatory T-cell-specific Signature With Potential Implications in Prognosis, Immunotherapy, and Therapeutic Resistance of Prostate Cancer

Abstract: Prostate cancer, recognized as a “cold” tumor, has an immunosuppressive microenvironment in which regulatory T cells (Tregs) usually play a major role. Therefore, identifying a prognostic signature of Tregs has promising benefits of improving survival of prostate cancer patients. However, the traditional methods of Treg quantification usually suffer from bias and variability. Transcriptional characteristics have recently been found to have a predictive power for the infiltration of Tregs. Thus, a novel machine… Show more

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Cited by 5 publications
(2 citation statements)
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“…For example, MDSCs present in the TME have been shown to release IL23, which activates STAT3-RORγ signaling to drive AR transcription and castration resistance ( Calcinotto et al, 2018 ). In addition, the immunosuppressive prostate TME is characterized by increased TGF-β expression by prostate tissue, poor cytolytic activity of NK cells and the presence of regulatory T cells ( Sfanos et al, 2008 ; Pasero et al, 2016 ; Ahel et al, 2019 ; Ge et al, 2022 ; Ju et al, 2022 ). Paradoxically, the presence of neutrophils is associated with poor prognosis and tumor infiltration with CD4 + T cells has been linked to tumor progression and metastasis ( Hu et al, 2015 ; Wu et al, 2020 ).…”
Section: Current Microphysiological Systems Of ‘Cold’ Tumorsmentioning
confidence: 99%
“…For example, MDSCs present in the TME have been shown to release IL23, which activates STAT3-RORγ signaling to drive AR transcription and castration resistance ( Calcinotto et al, 2018 ). In addition, the immunosuppressive prostate TME is characterized by increased TGF-β expression by prostate tissue, poor cytolytic activity of NK cells and the presence of regulatory T cells ( Sfanos et al, 2008 ; Pasero et al, 2016 ; Ahel et al, 2019 ; Ge et al, 2022 ; Ju et al, 2022 ). Paradoxically, the presence of neutrophils is associated with poor prognosis and tumor infiltration with CD4 + T cells has been linked to tumor progression and metastasis ( Hu et al, 2015 ; Wu et al, 2020 ).…”
Section: Current Microphysiological Systems Of ‘Cold’ Tumorsmentioning
confidence: 99%
“…10 In addition, Tregs manipulate the metabolism of effector immune cells, 11 thus influencing their functions. Importantly, Tregs are linked to unfavorable prognoses in solid cancers, such as prostate cancer, 12 OC, 13 and gastric cancer, 14 underscoring the need to target Tregs when treating cancer. Altering the proportion of Tregs or their signaling pathways within the tumor microenvironment (TME) and reversing the resultant immunosuppression may improve treatment outcomes with immune checkpoint inhibitors.…”
Section: Introductionmentioning
confidence: 99%