2014
DOI: 10.3906/biy-1401-50
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Computational regulatory model for detoxification of ammonia from urea cycle in liver

Abstract: A nondeterministic finite automaton was designed to monitor enzymatic regulation and detoxification of excess ammonia in the urea cycle and its disorders. The designed machine is used for the diagnosis of deficiency and for regulating the expression of any of the enzymes involved with acceptance and rejection states in the urea cycle. The urea cycle is the metabolism of excess nitrogen produced by the breakdown of protein and other nitrogen-containing molecules in liver. Disorder in the urea cycle may lead to … Show more

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Cited by 5 publications
(1 citation statement)
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“…Such a machine assists in scrutinizing the completion of urea cycle for degradation of ammonia into urea which is then excreted. This computational model also suggests the regulation of the enzymatic activity which can serve as a therapeutic application focusing on molecular targeted treatment for urea cycle disorders (UCD), brain damage and other related deficiencies due to ammonia toxicity (Ali et al 2014). …”
Section: Automatamentioning
confidence: 99%
“…Such a machine assists in scrutinizing the completion of urea cycle for degradation of ammonia into urea which is then excreted. This computational model also suggests the regulation of the enzymatic activity which can serve as a therapeutic application focusing on molecular targeted treatment for urea cycle disorders (UCD), brain damage and other related deficiencies due to ammonia toxicity (Ali et al 2014). …”
Section: Automatamentioning
confidence: 99%