Computational Simulation of the Adaptive Capacity of Vein Grafts in Response to Increased Pressure

Ramachandra, Abhay B.; Sankaran, Sethuraman; Humphrey, Jay D.; Marsden, Alison L.

doi:10.1115/1.4029021

Cited by 34 publications

(27 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many theoretical studies have been proposed using stress-based growth and remodeling process for CABG for venous grafts and the current study has established the initial conditions for those future investigations which will determine the adaptability of the candidate tissues to new environments (Hwang et al, 2012; Ramachandra et al, 2014). We hypothesize that adaptability is dependent upon cellular function and the current state of the extra cellular matrix.…”

Section: Discussionmentioning

confidence: 99%

A mechanical argument for the differential performance of coronary artery grafts

Prim

Zhou

Hartstone‐Rose

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

Coronary artery bypass grafting (CABG) acutely disturbs the homeostatic state of the transplanted vessel making retention of graft patency dependent on chronic remodeling processes. The time course and extent to which remodeling restores vessel homeostasis will depend, in part, on the nature and magnitude of the mechanical disturbances induced upon transplantation. In this investigation, biaxial mechanical testing and histology were performed on the porcine left anterior descending artery (LAD) and analogs of common autografts, including the internal thoracic artery (ITA), radial artery (RA), great saphenous vein (GSV) and lateral saphenous vein (LSV). Experimental data were used to quantify the parameters of a structure-based constitutive model enabling prediction of the acute vessel mechanical response pre-transplantation and under coronary loading conditions. A novel metric Ξ was developed to quantify mechanical differences between each graft vessel in situ and the LAD in situ, while a second metric Ω compares the graft vessels in situ to their state under coronary loading. The relative values of these metrics among candidate autograft sources are consistent with vessel-specific variations in CABG clinical success rates with the ITA as the superior and GSV the inferior graft choices based on mechanical performance. This approach can be used to evaluate other candidate tissues for grafting or to aid in the development of synthetic and tissue engineered alternatives.

show abstract

Section: Discussionmentioning

confidence: 99%

A mechanical argument for the differential performance of coronary artery grafts

Prim

Zhou

Hartstone‐Rose

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

show abstract

“…Vascular growth and remodeling describes changes in thickness, radius and wall composition of a vessel wall in response to changing hemodynamic forces. Recent work has expanded models of arterial growth and remodeling to veins[35], coupled CFD and G&R models in the context of adult cardiology,[36] and applied rigorous approaches for parameter selection. [37] Applications of G&R to pediatrics will require modifications to existing models to account for differing biologic and material responses in children.…”

Section: Advances In Modeling Methodsmentioning

confidence: 99%

Computational modeling and engineering in pediatric and congenital heart disease

Marsden¹,

Feinstein

2015

Current Opinion in Pediatrics

Self Cite

View full text Add to dashboard Cite

Purpose of review Recent methodological advances in computational simulations are enabling increasingly realistic simulations of hemodynamics and physiology, driving increased clinical utility. We review recent developments in the use of computational simulations in pediatric and congenital heart disease, describe the clinical impact in modeling in single ventricle patients, and provide an overview of emerging areas. Recent Findings Multiscale modeling combining patient specific hemodynamics with reduced order (i.e. mathematically and computationally simplified) circulatory models has become the defacto standard for modeling local hemodynamics and “global” circulatory physiology. We review recent advances that have enabled faster solutions, discuss new methods, (e.g. fluid structure interaction and uncertainty quantification), which lend realism both computationally and clinically to results, highlight novel computationally-derived surgical methods for single ventricle patients, and discuss areas in which modeling has begun to exert its influence including Kawasaki disease, fetal circulation, tetralogy of Fallot, (and pulmonary tree), and circulatory support. Summary Computational modeling is emerging as a crucial tool for clinical decision-making and evaluation of novel surgical methods and interventions in pediatric cardiology and beyond. Continued development of modeling methods, with an eye towards clinical needs, will enable clinical adoption in a wide range of pediatric and congenital heart diseases.

show abstract

“…This study also determined that prestretch of collagen and elastin played a role in homeostasis, whereas material properties determined response time [13]. Similar work has been performed to study other clinically relevant vascular diseases, including an infrarenal aorta model to study expansion of aneurysms and vein grafts in response to increased pressure [14, 15]. …”

Section: The Vascular Systemmentioning

confidence: 96%

Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease

Randles

Leopold

2017

Trends in Biotechnology

View full text Add to dashboard Cite

Non-invasive engineering models are now being used for diagnosing and planning the treatment of cardiovascular disease. Techniques in computational modeling and additive manufacturing have matured concurrently, and results from simulations can inform and enable the design and optimization of therapeutic devices and treatment strategies. The emerging synergy between large-scale simulations and 3D printing is having a two-fold benefit: first, 3D printing can be used to validate the complex simulations, and second, the flow models can be used to improve treatment planning for cardiovascular disease. In this review, we summarize and discuss recent methods and findings for leveraging advances in both additive manufacturing and patient-specific computational modeling, with an emphasis on new directions in these fields and remaining open questions.

show abstract

Computational Simulation of the Adaptive Capacity of Vein Grafts in Response to Increased Pressure

Cited by 34 publications

References 54 publications

A mechanical argument for the differential performance of coronary artery grafts

A mechanical argument for the differential performance of coronary artery grafts

Computational modeling and engineering in pediatric and congenital heart disease

Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease

Contact Info

Product

Resources

About