This paper presents a panoramic view of research on economic and financial networks in the journal Networks, since its inception half a century ago. This paper focuses on both the breadth and depth of the journal articles, and within the context of earlier contributions, as well as more recent related ones in other scientific publications. From network optimization to game theory and a plethora of equilibrium concepts, along with novel dynamical systems frameworks, the journal has led the way in advancing economic and financial network models, algorithms, and applications. Moreover, Networks has helped to attract researchers in a variety of disciplines to the science of networks and the formulation and solution of associated problems drawn from the real world. KEYWORDS economic networks, financial equilibrium, financial networks, game theory, projected dynamical systems, spatial price equilibrium, variational inequalities 1 INTRODUCTION Networks, from transportation and logistical ones, to communications and energy, have provided the foundation and connectivity for the flow of people, and the exchange of goods, information, and services across space and time. Intimately related to such physical networks, in which the identification of nodes, links, and associated flows with physical entities is well-understood, are economic and financial networks. The importance of all such network systems to the functioning of our societies and economies, coupled with the need to understand their interrelationships, has spurred numerous advances in methodologies for their modeling, analysis, and solution, under different behavioral concepts associated with usage and management. The origins of network theory can be traced back to the 1700s, to the classical paper of Euler [64], the earliest paper on graph theory. By a graph in this context is meant, mathematically, a means of abstractly representing a system by its representation in terms of vertices (or nodes) and edges (arcs or, equivalently, links) joining pairs of vertices. Euler sought to determine whether it was possible to walk around Königsberg (later renamed Kaliningrad) by crossing the seven bridges over the River Pregel exactly once. The problem was depicted as a graph with the vertices representing land masses and the edges-bridges. Interestingly, one of the first network models was for a financial system. Specifically, Quesnay [188], in his Tableau Economique, conceptualized the circular flow of financial funds in an economy as a network. His fundamental idea has been utilized in the construction of financial flow of funds accounts, which provide a statistical description of the flows of money and credit in an economy [37]. This work also inspired the first paper on financial networks in Networks, by Nagurney and Hughes [144]. The network model, with an accompanying decomposition algorithm, can be applied to calculate reconciled values of outstanding financial instruments, tangible assets, and net worth. The reconciled dataset can then be utilized as a base line for ...