Computed Body Tomography with Iopamidol

Contrast-enhanced CT of the liver and spleen: comparison of ionic and nonionic contrast agents

“…In the spleen, however, the postcontrast enhancement with each of the two agents was not statistically different, as was the case in our study. In yet another study [13], no statistical difference was found between hepatic and splenic enhancement after the IV administration of diatrizoate-60 and iopamidol-300.…”

Contrast Enhancement of the Upper Abdomen Evaluated BY CT

“…Regarding the detectability of lesions in the liver (which is dependent on the contrast enhancement within the parenchyma) controversial results have been published with different contrast media. Some studies have shown that there is no difference between non-ionic media compared with ionic media (7,12,14,15,17,18). DEAN et al (7) showed that there were different concentrations of iodine in the tissues of the spleen and liver following metrizamide, iopamidol and iohexol injections.…”

Acute Systemic Reactions to Intravascular Contrast Media –a planned approach

“…Such nonionic contrast media do not require a salifyhg cation, and therefore have a lower osmolality than ionic contrast media with a corresponding iodine concentration. While initial interest focused on the reduced neurotoxicity of the nonionic contrast media, subsequent animal ex-periments9.10.11 and clinical trials 12,13,14,15,16 indicated a reduced local and systemic toxicity following intravascular administration. Clinical trials with intravenous iopamidol and iohexol have indicated that there is a reduced incidence of mild, moderate and severe reactions with such contrast media when compared with corresponding iodine concentrations of ionic contrast media 12.W43.16. Preliminary reports 16 and communications17 also suggest that the risk of fatal reactions is reduced by the use of non-ionic rather than ionic contrast media.…”